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Bebenek K

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Publications:

Title Authors Year Journal
Sustained active site rigidity during synthesis by human DNA polymerase μ. Bebenek K 2014 Nature structural & molecular biology
DNA Polymerase λ Inactivation by Oxidized Abasic Sites. Bebenek K 2013 Biochemistry
Altered Ig Hypermutation Pattern and Frequency in Complementary Mouse Models of DNA Polymerase ζ Activity. Bebenek K 2012 Journal of immunology (Baltimore, Md. : 1950)
The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ Bebenek K 2012 Nucleic acids research
Replication infidelity via a mismatch with Watson-Crick geometry. Bebenek K 2011 Proceedings of the National Academy of Sciences of the United States of America
Loop 1 modulates the fidelity of DNA polymerase {lambda} Bebenek K 2010 Nucleic acids research
Inhibition of short patch and long patch base excision repair by an oxidized abasic site. Bebenek K 2010 Biochemistry
Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. Bebenek K 2009 PloS one
Template strand scrunching during DNA gap repair synthesis by human polymerase lambda. Bebenek K 2009 Nature structural & molecular biology
Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts. Bebenek K 2008 Nucleic acids research
Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda. Bebenek K 2008 EMBO Rep
Catalytic mechanism of human DNA polymerase lambda with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies. Bebenek K 2008 DNA repair
The X family portrait: structural insights into biological functions of X family polymerases. Bebenek K 2007 DNA repair
Multiple functions of DNA polymerases. Bebenek K 2007 Critical reviews in plant sciences
Role of the catalytic metal during polymerization by DNA polymerase lambda. Bebenek K 2007 DNA repair
Structural insight into the substrate specificity of DNA Polymerase mu. Bebenek K 2007 Nature structural & molecular biology
RNA-templated DNA repair. Bebenek K 2007 Nature
Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase. Bebenek K 2006 Cell
Promiscuous mismatch extension by human DNA polymerase lambda. Bebenek K 2006 Nucleic acids research
A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Bebenek K 2005 Molecular cell
Structure-function studies of DNA polymerase lambda. Bebenek K 2005 DNA repair
A lysine residue in the fingers subdomain of T7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine. Bebenek K 2005 Structure (London, England : 1993)
A closed conformation for the Pol lambda catalytic cycle. Bebenek K 2005 Nature structural & molecular biology
Biochemical properties of Saccharomyces cerevisiae DNA polymerase IV. Bebenek K 2005 The Journal of biological chemistry
Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Bebenek K 2004 Cancer research
Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. Bebenek K 2004 The Journal of biological chemistry
Functions of DNA polymerases. Bebenek K 2004 Adv Protein Chem
A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Bebenek K 2004 Molecular cell
Solution structure of the lyase domain of human DNA polymerase lambda. Bebenek K 2003 Biochemistry
The frameshift infidelity of human DNA polymerase lambda. Implications for function. Bebenek K 2003 The Journal of biological chemistry
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. Bebenek K 2003 DNA repair
The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair. Bebenek K 2003 The Journal of biological chemistry
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. Bebenek K 2003 The Journal of biological chemistry
Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site. Bebenek K 2002 The Journal of biological chemistry
Family growth: the eukaryotic DNA polymerase revolution. Bebenek K 2002 Cell Mol Life Sci
DNA polymerase lambda, a novel DNA repair enzyme in human cells. Bebenek K 2002 The Journal of biological chemistry
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Bebenek K 2001 Nat Immunol
Error rate and specificity of human and murine DNA polymerase eta. Bebenek K 2001 Journal of molecular biology
Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. Bebenek K 2001 The Journal of biological chemistry
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Bebenek K 2001 Science
Proofreading of DNA polymerase eta-dependent replication errors. Bebenek K 2001 The Journal of biological chemistry
DNA replication fidelity. Bebenek K 2000 Annual review of biochemistry
Human DNA polymerase kappa: a novel DNA polymerase of unknown biological function encoded by the DINB1 gene. Bebenek K 2000 Cold Spring Harbor symposia on quantitative biology
Low fidelity DNA synthesis by human DNA polymerase-eta. Bebenek K 2000 Nature
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. Bebenek K 2000 The Journal of biological chemistry
Vertical-scanning mutagenesis of a critical tryptophan in the "minor groove binding track" of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove. Bebenek K 2000 The Journal of biological chemistry
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment). Bebenek K 1999 The Journal of biological chemistry
Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase. Bebenek K 1999 The Journal of biological chemistry
Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer. Bebenek K 1999 The Journal of biological chemistry
The base substitution fidelity of HIV-1 reverse transcriptase on DNA and RNA templates probed with 8-oxo-deoxyguanosine triphosphate. Bebenek K 1999 Mutation research
Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions. Bebenek K 1998 The Journal of biological chemistry
A minor groove binding track in reverse transcriptase. Bebenek K 1997 Nat Struct Biol
Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts. Bebenek K 1997 The Journal of biological chemistry
Exonucleolytic proofreading during replication of repetitive DNA. Bebenek K 1996 Biochemistry
Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain. Bebenek K 1995 The Journal of biological chemistry
Analyzing fidelity of DNA polymerases. Bebenek K 1995 Methods in enzymology
Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain. Bebenek K 1994 The Journal of biological chemistry
Structure/function studies of HIV-1(1) reverse transcriptase: dimerization-defective mutant L289K. Bebenek K 1993 Biochemistry
Mechanism of HIV-1 reverse transcriptase. Termination of processive synthesis on a natural DNA template is influenced by the sequence of the template-primer stem. Bebenek K 1993 The Journal of biological chemistry
Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. Bebenek K 1993 The Journal of biological chemistry
Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine. Bebenek K 1992 The Journal of biological chemistry
Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates. Bebenek K 1992 Proceedings of the National Academy of Sciences of the United States of America
The effects of dNTP pool imbalances on frameshift fidelity during DNA replication. Bebenek K 1992 The Journal of biological chemistry
Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme. Bebenek K 1990 The Journal of biological chemistry
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. Bebenek K 1990 The Journal of biological chemistry
Frameshift errors initiated by nucleotide misincorporation. Bebenek K 1990 Proceedings of the National Academy of Sciences of the United States of America
Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. Bebenek K 1989 The Journal of biological chemistry
The use of native T7 DNA polymerase for site-directed mutagenesis. Bebenek K 1989 Nucleic acids research
The accuracy of reverse transcriptase from HIV-1. Bebenek K 1988 Science (New York, N.Y.)
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