RB69

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Welcome to the Polymerase Page

This page presents all the information in Polbase for RB69.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

RB69 is a family B enzyme from Bacteriophage RB69.

Selected Properties for RB69:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (1) no data no data no data no data
Year Authors Title Results by property
2015 Hariyanto Darmawan, Melissa Harrison, Linda J Reha-Krantz DNA polymerase 3'→5' exonuclease acti...
2013 Shuangluo Xia, Marcus Wood, Michael J Bradley, Enrique M De La Cruz, William H Konigsberg Alteration in the cavity size adjacen...
2012 Shuangluo Xia, Jeff W Beckman, Jianhong Wang, William H Konigsberg Using a Fluorescent Cytosine Analogue...
2012 Shuangluo Xia, Soo Hyun Eom, William H Konigsberg, Jianhong Wang Structural Basis for Differential Ins...
2012 Shuangluo Xia, Soo Hyun Eom, William H Konigsberg, Jianhong Wang Bidendate and tridendate metal-ion co...
2012 Shuangluo Xia, Ashwani Kumar Vashishtha, David Bulkley, Soo Hyun Eom, Jianhong Wang, William H Konigsberg Contribution of Partial Charge Intera...
2011 M Hogg, AE Sauer-Eriksson, Erik Johansson Promiscuous DNA synthesis by human DN...
2011 Michael Wang, Shuangluo Xia, Gregor Blaha, Thomas A Steitz, William H Konigsberg, Jianhong Wang Insights into Base Selectivity from t...
2011 Shuangluo Xia, Michael Wang, Gregor Blaha, William H Konigsberg, Jianhong Wang Structural Insights into Complete Met...
2011 Shuangluo Xia, William H Konigsberg, Jianhong Wang Hydrogen-bonding capability of a temp...
2011 Shuangluo Xia, Michael Wang, Harold R Lee, Arjun Sinha, Gregor Blaha, Thomas David Christian, Jianhong Wang, William H Konigsberg Variation in Mutation Rates Caused by...
2010 Vasiliy M Petrov, Swarnamala Ratnayaka, Jim D Karam Genetic insertions and diversificatio...
2010 Kei-ichi Takata, Mercedes E Arana, Masayuki Seki, Thomas A Kunkel, Richard D Wood Evolutionary conservation of residues...
2010 Anna Trzemecka, Agata Jacewicz, Geraldine T Carver, John W Drake, Anna Bebenek Reversal of a mutator activity by a n...
2010 Linda J Reha-Krantz DNA polymerase proofreading: Multiple...
2010 Jeff W Beckman, Michael Wang, Gregor Blaha, Jianhong Wang, William H Konigsberg Substitution of Ala for Tyr567 in RB6...
2010 Jeff W Beckman, Michael Wang, Gregor Blaha, Jianhong Wang, William H Konigsberg Substitution of Ala for Tyr567 in RB6...
2010 Matthew Hogg, Jean Rudnicki, John Midkiff, Linda J Reha-Krantz, Sylvie Doublié, Susan S Wallace Kinetics of mismatch formation opposi...
2009 Haijiang Zhang, Jeff W Beckman, Jianhong Wang, William H Konigsberg RB69 DNA polymerase mutants with expa...
2009 Michael Wang, Harold R Lee, William H Konigsberg Effect of A and B metal ion site occu...
2009 Harold R Lee, Michael Wang, William H Konigsberg The reopening rate of the fingers dom...
2009 Egor P Tchesnokov, Aleksandr Obikhod, Raymond F Schinazi, Matthias Götte Engineering of a chimeric RB69 DNA po...
2009 Anna Trzemecka, Danuta Płochocka, Anna Bebenek Different behaviors in vivo of mutati... Kd,All properties
2008 Usharani Subuddhi, Matthew Hogg, Linda J Reha-Krantz Use of 2-aminopurine fluorescence to ...
2008 Xuejun Zhong, Lars C Pedersen, Thomas A Kunkel Characterization of a replicative DNA...
2007 Haijiang Zhang, W Cao, E Zakharova, William H Konigsberg, E M De La Cruz Fluorescence of 2-aminopurine reveals...
2007 Pierre Aller, Mark A Rould, Matthew Hogg, Susan S Wallace, Sylvie Doublié A structural rationale for stalling o...
2007 Karl E Zahn, Hassan Belrhali, Susan S Wallace, Sylvie Doublié Caught bending the A-rule: crystal st...
2007 Christian Castro, Eric D Smidansky, Kenneth R Maksimchuk, Jamie J Arnold, Victoria S Korneeva, Matthias Götte, William H Konigsberg, Craig E Cameron Two proton transfers in the transitio...
2007 Agata Jacewicz, Karolina Makiela, Andrzej Kierzek, John W Drake, Anna Bebenek The roles of Tyr391 and Tyr619 in RB6...
2007 Matthew Hogg, Pierre Aller, William H Konigsberg, Susan S Wallace, Sylvie Doublié Structural and biochemical investigat... 3-5' exo,All properties
2007 Dina Tleugabulova, Linda J Reha-Krantz Probing DNA polymerase-DNA interactio...
2006 Vasiliy M Petrov, James M Nolan, Claire Bertrand, Dawn Levy, Carine Desplats, H M Krisch, Jim D Karam Plasticity of the gene functions for ...
2006 Siyang Sun, Linda Geng, Yousif Shamoo Structure and enzymatic properties of... Cloned or native,Full length or truncated,Processivity,Kd,All properties
2006 Haijiang Zhang, Chanu Rhee, Anna Bebenek, John W Drake, Jianhong Wang, William H Konigsberg The L561A substitution in the nascent... Kd,kcat,All properties
2006 Matthew Hogg, Wendy Cooper, Linda J Reha-Krantz, Susan S Wallace Kinetics of error generation in homol...
2005 Guangwei Yang, Jianhong Wang, William H Konigsberg Base selectivity is impaired by mutan...
2005 John W Drake, Anna Bebenek, Grace E Kissling, Shyamal Peddada Clusters of mutations from transient ...
2005 Anna Bebenek, Geraldine T Carver, Farid A Kadyrov, Grace E Kissling, John W Drake Processivity clamp gp45 and ssDNA-bin...
2005 Matthew Hogg, Susan S Wallace, Sylvie Doublié Bumps in the road: how replicative DN...
2004 Eva Freisinger, Arthur P Grollman, Holly Miller, Caroline Kisker Lesion (in)tolerance reveals insights...
2004 E Zakharova, Jianhong Wang, William H Konigsberg The activity of selected RB69 DNA pol...
2004 Matthew Hogg, Susan S Wallace, Sylvie Doublié Crystallographic snapshots of a repli...
2004 C X Wang, E Zakharova, Jinming Li, Catherine M Joyce, Jianhong Wang, William H Konigsberg Pre-steady-state kinetics of RB69 DNA... kcat,All properties
2004 Vasiliy M Petrov, Jim D Karam Diversity of structure and function o...
2004 Andrew F Gardner, Catherine M Joyce, William E Jack Comparative kinetics of nucleotide an...
2003 William A Beard, Samuel H Wilson Structural insights into the origins ...
2003 Siyang Sun, Yousif Shamoo Biochemical characterization of inter...
2002 Guangwei Yang, Matthew Franklin, Jinming Li, T C Lin, William H Konigsberg Correlation of the kinetics of finger...
2002 David Jeruzalmi, Mike E O'Donnell, John Kuriyan Clamp loaders and sliding clamps.
2002 Vasiliy M Petrov, Jim D Karam RNA determinants of translational ope...
2002 Anna Bebenek, Geraldine T Carver, Holly Kloos Dressman, Farid A Kadyrov, Joseph K Haseman, Vasiliy M Petrov, William H Konigsberg, Jim D Karam, John W Drake Dissecting the fidelity of bacterioph...
2002 Vasiliy M Petrov, San-San Ng, Jim D Karam Protein determinants of RNA binding b...
2001 M C Franklin, Jianhong Wang, Thomas A Steitz Structure of the replicating complex ...
2001 Anna Bebenek, Holly Kloos Dressman, Geraldine T Carver, S Ng , Vasiliy M Petrov, Guangwei Yang, William H Konigsberg, Jim D Karam, John W Drake Interacting fidelity defects in the r...
1999 Guangwei Yang, T Lin, J Karam, William H Konigsberg Steady-state kinetic characterization...
1999 Thomas A Steitz DNA polymerases: structural diversity...
1999 J M Stattel, George E Wright Sensitivity of bacteriophage RB69 DNA...
1998 L A Smith, John W Drake Aspects of the ultraviolet photobiolo...
1998 L S Yeh, Tien Hsu, Jim D Karam Divergence of a DNA replication gene ...
1998 Nancy G Nossal A new look at old mutants of T4 DNA p...
1998 J Saturno, José María Lázaro, Luis Blanco, Margarita Salas Role of the first aspartate residue o...
1997 Holly Kloos Dressman, C C Wang, Jim D Karam, John W Drake Retention of replication fidelity by ...
1997 C C Wang, A Pavlov, Jim D Karam Evolution of RNA-binding specificity ...
1997 Jianhong Wang, A K Sattar, C C Wang, Jim D Karam, William H Konigsberg, Thomas A Steitz Crystal structure of a pol alpha fami...
1995 C C Wang, L S Yeh, Jim D Karam Modular organization of T4 DNA polyme...
1990 C Tuerk, S Eddy, D Parma, L Gold Autogenous translational operator rec...
Protein sequence:
DNA sequence:

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