Human Pol lamba
From
H. sapiens
(genes: POLL )
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol lamba.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Human Pol lamba
is a family X enzyme
from
H. sapiens.
Selected Properties for Human Pol lamba: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| No (3) | No (1) | 4.9e-03 errors/bp (1) | 9.0e-04-9.0e-04 errors/bp (2) | no data |
- References (59)
- Structures (29)
- Sequences (1)
- Mutants (1)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2013 | Adam J Stevens, Lirui Guan, Katarzyna Bebenek, Thomas A Kunkel, Marc M Greenberg | DNA Polymerase λ Inactivation by Oxid... | |
| 2013 | Tobias Strittmatter, Anette Brockmann, Moritz Pott, Annika Hantusch, Thomas Brunner, Andreas Marx | Expanding the Scope of Human DNA Poly... | |
| 2012 | Lidia V Skosareva, Natalia A Lebedeva, Nadejda I Rechkunova, Alexander Kolbanovskiy, Nicholas E Geacintov, Olga I Lavrik | Human DNA polymerase λ catalyzes lesi... | |
| 2012 | Rajendrakumar A Gosavi, Andrea F Moon, Thomas A Kunkel, Lars C Pedersen, Katarzyna Bebenek | The catalytic cycle for ribonucleotid... | |
| 2011 | Katarzyna Bebenek, Lars C Pedersen, Thomas A Kunkel | Replication infidelity via a mismatch... | |
| 2011 | Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida | Effects of quinone derivatives, such ... | |
| 2011 | Tobias Strittmatter, Bettina Bareth, Timo A Immel, Thomas Huhn, Thomas U Mayer, Andreas Marx | Small Molecule Inhibitors of Human DN... | |
| 2011 | Enni Markkanen, Barbara van Loon, Elena Ferrari, Jason L Parsons, Grigory L Dianov, Ulrich Hübscher | Regulation of oxidative DNA damage re... | |
| 2011 | Emmanuele Crespan, Giovanni Maga, Ulrich Hübscher | A new proofreading mechanism for lesi... | |
| 2010 | Jennifer Yamtich, Joann B Sweasy | DNA polymerase family X: function, st... | Full length or truncated,Gap fill,Terminal Transferase,3-5' exo,5-3' exo,Molecular Weight,Vmax,Other accessory protein(s),Template lesions,All properties |
| 2010 | Jessica A Brown, Lindsey R Pack, Shanen M Sherrer, Ajay K Kshetry, Sean A Newmister, Jason D Fowler, John-Stephen Taylor, Zucai Suo | Identification of critical residues f... | |
| 2010 | Miguel Garcia-Diaz, Michael S Murray, Thomas A Kunkel, Kai-Ming Chou | The interaction between DNA polymeras... | |
| 2010 | Lirui Guan, Katarzyna Bebenek, Thomas A Kunkel, Marc M Greenberg | Inhibition of short patch and long pa... | |
| 2010 | Katarzyna Bebenek, Miguel Garcia-Diaz, Rui-Zhe Zhou, Lawrence F Povirk, Thomas A Kunkel | Loop 1 modulates the fidelity of DNA ... | KM,kcat,All properties |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2010 | Jean-Pascal Capp, François Boudsocq, Valérie Bergoglio, Didier Trouche, Christophe Cazaux, Luis Blanco, Jean-Sébastien Hoffmann, Yvan Canitrot | The R438W polymorphism of human DNA p... | |
| 2009 | Jason D Fowler, Jessica A Brown, Mamuka Kvaratskhelia, Zucai Suo | Probing conformational changes of hum... | |
| 2009 | Gloria Terrados, Jean-Pascal Capp, Yvan Canitrot, Miguel García-Díaz, Katarzyna Bebenek, Tomas Kirchhoff, Alberto Villanueva, François Boudsocq, Valérie Bergoglio, Christophe Cazaux, Thomas A Kunkel, Jean-Sébastien Hoffmann, Luis Blanco | Characterization of a natural mutator... | |
| 2009 | Barbara van Loon, Ulrich Hübscher | An 8-oxo-guanine repair pathway coord... | |
| 2008 | Giovanni Maga, Emmanuele Crespan, Ursula Wimmer, Barbara van Loon, Alessandra Amoroso, Chiara Mondello, Cristina Belgiovine, Elena Ferrari, Giada A Locatelli, Giuseppe Villani, Ulrich Hübscher | Replication protein A and proliferati... | |
| 2008 | Masayuki Nishida, Noriko Ida, Mao Horio, Toshifumi Takeuchi, Shinji Kamisuki, Hiroshi Murata, Kouji Kuramochi, Fumio Sugawara, Hiromi Yoshida, Yoshiyuki Mizushina | Hymenoic acid, a novel specific inhib... | |
| 2008 | Vinod K Batra, William A Beard, David D Shock, Lars C Pedersen, Samuel H Wilson | Structures of DNA polymerase beta wit... | |
| 2008 | Katarzyna Bebenek, Miguel Garcia-Diaz, Meredith C Foley, Lars C Pedersen, Tamar Schlick, Thomas A Kunkel | Substrate-induced DNA strand misalign... | |
| 2008 | Patrick P Lestienne, François Boudsocq, Jacques E Bonnet | Initiation of DNA replication by a th... | |
| 2008 | G Andrés Cisneros, Lalith Perera, Miguel García-Díaz, Katarzyna Bebenek, Thomas A Kunkel, Lee G Pedersen | Catalytic mechanism of human DNA poly... | |
| 2007 | Angel J Picher, Luis Blanco | Human DNA polymerase lambda is a prof... | |
| 2007 | Andrea F Moon, Miguel Garcia-Diaz, Vinod K Batra, William A Beard, Katarzyna Bebenek, Thomas A Kunkel, Samuel H Wilson, Lars C Pedersen | The X family portrait: structural ins... | |
| 2007 | Robert S Pitcher, Nigel C Brissett, Angel J Picher, Paula Andrade, Raquel Juarez, Darren Thompson, Gavin C Fox, Luis Blanco, Aidan J Doherty | Structure and function of a mycobacte... | Terminal Transferase,All properties |
| 2007 | Fu Gu, Chun You, JianPing Liu, Ao Chen, Yao Yu, Xiang Wang, DaFang Wan, JianRen Gu, HanYing Yuan, Yingqian Li, Hong Lü | Cloning, expression and characterizat... | |
| 2007 | Shinji Kamisuki, Chisato Ishimaru, Kadohiro Onoda, Isoko Kuriyama, Noriko Ida, Fumio Sugawara, Hiromi Yoshida, Yoshiyuki Mizushina | Nodulisporol and Nodulisporone, novel... | |
| 2007 | Jessica A Brown, Wade W Duym, Jason D Fowler, Zucai Suo | Single-turnover kinetic analysis of t... | |
| 2007 | Miguel Garcia-Diaz, Katarzyna Bebenek, Joseph M Krahn, Lars C Pedersen, Thomas A Kunkel | Role of the catalytic metal during po... | |
| 2007 | Emmanuele Crespan, Ulrich Hübscher, Giovanni Maga | Error-free bypass of 2-hydroxyadenine... | |
| 2006 | Kevin A Fiala, Wade W Duym, Jun Zhang, Zucai Suo | Up-regulation of the fidelity of huma... | |
| 2006 | Miguel Garcia-Diaz, Katarzyna Bebenek, Joseph M Krahn, Lars C Pedersen, Thomas A Kunkel | Structural analysis of strand misalig... | |
| 2006 | Toshifumi Takeuchi, Tomomi Ishidoh, Hiroshi Iijima, Isoko Kuriyama, Noriko Shimazaki, Osamu Koiwai, Kouji Kuramochi, Susumu Kobayashi, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina | Structural relationship of curcumin d... | |
| 2006 | Wade W Duym, Kevin A Fiala, Nikunj Bhatt, Zucai Suo | Kinetic effect of a downstream strand... | |
| 2006 | Giovanni Maga, Igor V Shevelev, Giuseppe Villani, Silvio Spadari, Ulrich Hübscher | Human replication protein A can suppr... | |
| 2006 | Angel J Picher, Miguel García-Díaz, Katarzyna Bebenek, Lars C Pedersen, Thomas A Kunkel, Luis Blanco | Promiscuous mismatch extension by hum... | |
| 2005 | Miguel Garcia-Diaz, Katarzyna Bebenek, Joseph M Krahn, Thomas A Kunkel, Lars C Pedersen | A closed conformation for the Pol lam... | |
| 2005 | Giovanni Maga, Kristijan Ramadan, Giada A Locatelli, Igor V Shevelev, Silvio Spadari, Ulrich Hübscher | DNA elongation by the human DNA polym... | |
| 2005 | Isabelle Frouin, Magali Toueille, Elena Ferrari, Igor V Shevelev, Ulrich Hübscher | Phosphorylation of human DNA polymera... | |
| 2005 | Emmanuele Crespan, Samantha Zanoli, Anastasiya Khandazhinskaya, Igor V Shevelev, Maxim Jasko, Ludmila Alexandrova, Marina Kukhanova, Giuseppina Blanca, Giuseppe Villani, Ulrich Hübscher, Silvio Spadari, Giovanni Maga | Incorporation of non-nucleoside triph... | |
| 2004 | Miguel Garcia-Diaz, Katarzyna Bebenek, Joseph M Krahn, Luis Blanco, Thomas A Kunkel, Lars C Pedersen | A structural solution for the DNA pol... | |
| 2004 | Kevin A Fiala, Wissam Abdel-Gawad, Zucai Suo | Pre-steady-state kinetic studies of t... | |
| 2004 | Kristijan Ramadan, Igor V Shevelev, Giovanni Maga, Ulrich Hübscher | De novo DNA synthesis by human DNA po... | |
| 2004 | Giuseppina Blanca, Giuseppe Villani, Igor V Shevelev, Kristijan Ramadan, Silvio Spadari, Ulrich Hübscher, Giovanni Maga | Human DNA polymerases lambda and beta... | |
| 2004 | Giovanni Maga, Giuseppina Blanca, Igor V Shevelev, Isabelle Frouin, Kristijan Ramadan, Silvio Spadari, Giuseppe Villani, Ulrich Hübscher | The human DNA polymerase lambda inter... | |
| 2003 | Giuseppina Blanca, Igor V Shevelev, Kristijan Ramadan, Giuseppe Villani, Silvio Spadari, Ulrich Hübscher, Giovanni Maga | Human DNA polymerase lambda diverged ... | |
| 2003 | Igor V Shevelev, Giuseppina Blanca, Giuseppe Villani, Kristijan Ramadan, Silvio Spadari, Ulrich Hübscher, Giovanni Maga | Mutagenesis of human DNA polymerase l... | |
| 2003 | Kristijan Ramadan, Giovanni Maga, Igor V Shevelev, Giuseppe Villani, Luis Blanco, Ulrich Hübscher | Human DNA polymerase lambda possesses... | |
| 2003 | Eugene F DeRose, Thomas W Kirby, Geoffrey A Mueller, Katarzyna Bebenek, Miguel Garcia-Diaz, Luis Blanco, Thomas A Kunkel, Robert E London | Solution structure of the lyase domai... | |
| 2003 | Katarzyna Bebenek, Miguel Garcia-Diaz, Luis Blanco, Thomas A Kunkel | The frameshift infidelity of human DN... | Full length or truncated,Gap fill,Terminal Transferase,3-5' exo,Frameshift Error Rate,Nucleotide Substitution Rate,All properties |
| 2002 | Noriko Shimazaki, Kenta Yoshida, Toshiko Kobayashi, Shingo Toji, Katsuyuki Tamai, Osamu Koiwai | Over-expression of human DNA polymera... | Cloned or native,Tagged,Tag Name,Full length or truncated,Specific Activity,Processivity,Molecular Weight,All properties |
| 2002 | Ulrich Hubscher, Giovanni Maga, Silvio Spadari | Eukaryotic DNA polymerases. | |
| 2002 | Yoshiyuki Mizushina, Shinji Kamisuki, Nobuyuki Kasai, Tomomi Ishidoh, Noriko Shimazaki, Masaharu Takemura, Hitomi Asahara, Stuart Linn, Shonen Yoshida, Osamu Koiwai, Fumio Sugawara, Hiromi Yoshida, Kengo Sakaguchi | Petasiphenol: a DNA polymerase lambda... | |
| 2002 | Miguel García-Díaz, Katarzyna Bebenek, Rosario Sabariegos, Orlando Domínguez, Josana Rodríguez, Tomas Kirchhoff, Esther García-Palomero, Angel J Picher, Raquel Juárez, José F Ruiz, Thomas A Kunkel, Luis Blanco | DNA polymerase lambda, a novel DNA re... | Cloned or native,Full length or truncated,Processivity,3-5' exo,Nucleotide Substitution Rate,KM,Molecular Weight,All properties |
| 2002 | Giovanni Maga, Giuseppe Villani, Kristijan Ramadan, Igor V Shevelev, Nicolas Tanguy Le Gac, Luis Blanco, Giuseppina Blanca, Silvio Spadari, Ulrich Hübscher | Human DNA polymerase lambda functiona... | |
| 2001 | Miguel García-Díaz, Katarzyna Bebenek, Thomas A Kunkel, Luis Blanco | Identification of an intrinsic 5'-deo... |
Protein sequence:
Predicted Structure Model
Predicted model
AlphaFold DB
Not experimentally determined
This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)
Confidence legend (pLDDT)
AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.
- Very high (pLDDT > 90) Backbone and side chains are usually reliable.
- Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
- Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
- Very low (pLDDT < 50) Often disordered or not confidently placed.
| Name | 3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Pol lamba L277A/H511A/R514 |
Protein information: Uniprot Q9UGP5 search for Human Pol lamba at UniProt
Sequence information: NCBI nucleotides European nucleotide archive
Predicted structure: AlphaFold DB entry AF-Q9UGP5-F1