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Results for property: Associated condition

Detailed Results for Property

Use this page to examine all the the polymerases and references referring to the property: Associated condition.

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Polymerase Kingdom Family Reference Result Context
Human Pol eta Eukaryote Y Emerging links between hypermutation of antibody genes and DNA polymerases. hypermutation and/or XERODERMA PIGMENTOSUM
Human Pol eta Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. UV sensitivity
Human Pol beta Eukaryote X DNA polymerase family X: function, structure, and cellular roles. I260M and K289M - Cancer
HIV RT Virus/Phage RT Nucleoside and nucleotide analogue reverse transcriptase inhibitors: a clinical review of antiretroviral resistance. HIV
HIV RT Virus/Phage RT Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains. HIV
HIV RT Virus/Phage RT TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. HIV
HIV RT Virus/Phage RT Nucleoside-analog resistance mutations in HIV-1 reverse transcriptase and their influence on polymerase fidelity and viral mutation rates. HIV
HIV RT Virus/Phage RT Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase. HIV
HIV RT Virus/Phage RT Exploring the effects of active site constraints on HIV-1 reverse transcriptase DNA polymerase fidelity. HIV
HIV RT Virus/Phage RT Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. HIV
HIV RT Virus/Phage RT Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design. HIV
HIV RT Virus/Phage RT Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2. HIV
HIV RT Virus/Phage RT Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase. HIV
HIV RT Virus/Phage RT Perspectives on the molecular mechanism of inhibition and toxicity of nucleoside analogs that target HIV-1 reverse transcriptase. HIV
HIV RT Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. HIV
HIV RT Virus/Phage RT Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA. HIV
Human Pol mu Eukaryote X Emerging links between hypermutation of antibody genes and DNA polymerases. hypermutation
Human Pol iota Eukaryote Y Emerging links between hypermutation of antibody genes and DNA polymerases. hypermutation
HIV RT E138K Virus/Phage RT Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138. HIV
HIV RT K103N Virus/Phage RT Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. HIV
HIV RT V108I Virus/Phage RT Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors. HIV
HIV RT L100I Virus/Phage RT Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors. HIV
HIV2 RT Virus/Phage RT Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors. AIDS
HIV RT M184V Virus/Phage RT Exploring the effects of active site constraints on HIV-1 reverse transcriptase DNA polymerase fidelity. HIV
Pol eta Y52E Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. UV sensitivity
Pol eta Y52D Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. UV sensitivity
Pol eta Y52H Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. UV sensitivity
Pol eta Y52F Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. UV sensitivity
Pol eta Y52A Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. UV sensitivity
HIV RT F61A Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. HIV
HIV RT F61W Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. HIV
HIV RT F61L Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. HIV
HIV RT F61Y Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. HIV
Sce pol gamma Eukaryote A Mitochondrial DNA defects in Saccharomyces cerevisiae caused by functional interactions between DNA polymerase gamma mutations associated with disease in human. PEO, Alpers
Mouse pol elta Eukaryote ? Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Cancer
Human Pol zeta Eukaryote B Emerging links between hypermutation of antibody genes and DNA polymerases. Somatic Hypermutation

Version:20240415

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.