Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy.
|
Hübscher U
|
|
Nucleosides & nucleotides
|
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
|
Hübscher U
|
|
Anticancer research
|
HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to bacterial penicillin-binding proteins.
|
Hübscher U
|
|
Methods and findings in experimental and clinical pharmacology
|
DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass.
|
Hübscher U
|
2013
|
Proceedings of the National Academy of Sciences of the United States of America
|
Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen.
|
Hübscher U
|
2012
|
ACS chemical biology
|
Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.
|
Hübscher U
|
2012
|
Nucleic acids research
|
Regulation of oxidative DNA damage repair: The adenine:8-oxo-guanine problem.
|
Hübscher U
|
2012
|
Cell cycle (Georgetown, Tex.)
|
Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.
|
Hübscher U
|
2012
|
Nucleic acids research
|
A new proofreading mechanism for lesion bypass by DNA polymerase-λ
|
Hübscher U
|
2011
|
EMBO reports
|
Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.
|
Hübscher U
|
2011
|
Proceedings of the National Academy of Sciences of the United States of America
|
Generation of a Mono-ubiquitinated PCNA Mimic by Click Chemistry.
|
Hübscher U
|
2011
|
Chembiochem : a European journal of chemical biology
|
DNA replication and repair bypass machines.
|
Hübscher U
|
2011
|
Current opinion in chemical biology
|
Ubiquitylation of DNA polymerase λ.
|
Hübscher U
|
2011
|
FEBS letters
|
Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine.
|
Hübscher U
|
2010
|
DNA repair
|
The family X DNA polymerase from Deinococcus radiodurans adopts a non-standard extended conformation.
|
Hübscher U
|
2009
|
The Journal of biological chemistry
|
An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda.
|
Hübscher U
|
2009
|
Proceedings of the National Academy of Sciences of the United States of America
|
The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1.
|
Hübscher U
|
2009
|
The Journal of biological chemistry
|
Isolation of recombinant DNA elongation proteins.
|
Hübscher U
|
2009
|
Methods in molecular biology (Clifton, N.J.)
|
Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair.
|
Hübscher U
|
2008
|
Proceedings of the National Academy of Sciences of the United States of America
|
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants.
|
Hübscher U
|
2008
|
Biochemical pharmacology
|
Control of DNA polymerase lambda stability by phosphorylation and ubiquitination during the cell cycle.
|
Hübscher U
|
2008
|
EMBO Rep
|
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
|
Hübscher U
|
2008
|
Nucleic acids research
|
Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen.
|
Hübscher U
|
2007
|
FASEB J
|
Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts.
|
Hübscher U
|
2007
|
Nucleic acids research
|
Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants.
|
Hübscher U
|
2007
|
ChemMedChem
|
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate.
|
Hübscher U
|
2007
|
Angewandte Chemie (International ed. in English)
|
The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair.
|
Hübscher U
|
2007
|
Nucleic acids research
|
Proteomic analysis of p16ink4a-binding proteins.
|
Hübscher U
|
2007
|
Proteomics
|
The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase.
|
Hübscher U
|
2007
|
EMBO Rep
|
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda.
|
Hübscher U
|
2007
|
Nucleic acids research
|
DNA polymerase X from Deinococcus radiodurans possesses a structure-modulated 3'-->5' exonuclease activity involved in radioresistance.
|
Hübscher U
|
2006
|
Molecular microbiology
|
Arginine methylation regulates DNA polymerase beta.
|
Hübscher U
|
2006
|
Molecular cell
|
Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda.
|
Hübscher U
|
2006
|
Nucleic acids research
|
Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen.
|
Hübscher U
|
2005
|
Nucleic acids research
|
Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta.
|
Hübscher U
|
2005
|
Mol Pharmacol
|
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.
|
Hübscher U
|
2005
|
Antimicrobial agents and chemotherapy
|
Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda.
|
Hübscher U
|
2005
|
Nucleic acids research
|
Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells.
|
Hübscher U
|
2005
|
Molecular pharmacology
|
DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.
|
Hübscher U
|
2005
|
The Journal of biological chemistry
|
The hyperthermophilic euryarchaeota Pyrococcus abyssi likely requires the two DNA polymerases D and B for DNA replication.
|
Hübscher U
|
2005
|
Journal of molecular biology
|
The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.
|
Hübscher U
|
2005
|
The Biochemical journal
|
De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase.
|
Hübscher U
|
2004
|
Journal of molecular biology
|
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex.
|
Hübscher U
|
2004
|
Antimicrobial agents and chemotherapy
|
Involvement of an X family DNA polymerase in double-stranded break repair in the radioresistant organism Deinococcus radiodurans.
|
Hübscher U
|
2004
|
Molecular microbiology
|
The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.
|
Hübscher U
|
2004
|
FASEB J
|
The DNA-polymerase-X family: controllers of DNA quality?
|
Hübscher U
|
2004
|
Nat Rev Mol Cell Biol
|
Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.
|
Hübscher U
|
2004
|
Biochemistry
|
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair.
|
Hübscher U
|
2004
|
Nucleic acids research
|
Multiple roles for kinases in DNA replication.
|
Hübscher U
|
2003
|
EMBO reports
|
Incorporation of reporter molecule-labeled nucleotides by DNA polymerases. II. High-density labeling of natural DNA.
|
Hübscher U
|
2003
|
Nucleic acids research
|
Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity.
|
Hübscher U
|
2003
|
The Journal of biological chemistry
|
DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA.
|
Hübscher U
|
2003
|
Journal of molecular biology
|
Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study.
|
Hübscher U
|
2003
|
Biochemistry
|
Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions.
|
Hübscher U
|
2003
|
Journal of molecular biology
|
Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.
|
Hübscher U
|
2003
|
Nucleic acids research
|
DNA polymerase lambda from calf thymus preferentially replicates damaged DNA.
|
Hübscher U
|
2002
|
The Journal of biological chemistry
|
DNA polymerase theta purified from human cells is a high-fidelity enzyme.
|
Hübscher U
|
2002
|
Journal of molecular biology
|
Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins.
|
Hübscher U
|
2002
|
Nucleic acids research
|
Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.
|
Hübscher U
|
2002
|
The Journal of biological chemistry
|
The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.
|
Hübscher U
|
2002
|
ScientificWorldJournal
|
Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins.
|
Hübscher U
|
2002
|
The EMBO journal
|
Replication factor C from the hyperthermophilic archaeon Pyrococcus abyssi does not need ATP hydrolysis for clamp-loading and contains a functionally conserved RFC PCNA-binding domain.
|
Hübscher U
|
2002
|
Journal of molecular biology
|
The 3' 5' exonucleases.
|
Hübscher U
|
2002
|
Nature reviews. Molecular cell biology
|
HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other.
|
Hübscher U
|
2001
|
FEBS letters
|
Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs.
|
Hübscher U
|
2001
|
Antimicrobial agents and chemotherapy
|
Replication of the lagging strand: a concert of at least 23 polypeptides.
|
Hübscher U
|
2001
|
Molecules and cells
|
Anti-HIV-1 activity in vitro of ceftazidime degradation products.
|
Hübscher U
|
2001
|
Antiviral chemistry & chemotherapy
|
A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis.
|
Hübscher U
|
2001
|
The Journal of biological chemistry
|
A coordinated interplay: proteins with multiple functions in DNA replication, DNA repair, cell cycle/checkpoint control, and transcription.
|
Hübscher U
|
2001
|
Progress in nucleic acid research and molecular biology
|
A unified nomenclature for the subunits of eukaryotic DNA polymerase delta.
|
Hübscher U
|
2001
|
Trends in biochemical sciences
|
Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1.
|
Hübscher U
|
2001
|
Proceedings of the National Academy of Sciences of the United States of America
|
Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.
|
Hübscher U
|
2001
|
The Journal of biological chemistry
|
A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation.
|
Hübscher U
|
2000
|
The Journal of biological chemistry
|
The N-terminal region of DNA polymerase delta catalytic subunit is necessary for holoenzyme function.
|
Hübscher U
|
2000
|
Nucleic acids research
|
DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase alpha at a critical length.
|
Hübscher U
|
2000
|
Journal of molecular biology
|
The PCNA from Thermococcus fumicolans functionally interacts with DNA polymerase delta.
|
Hübscher U
|
2000
|
Biochem Biophys Res Commun
|
Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK.
|
Hübscher U
|
2000
|
Genes & development
|
DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading.
|
Hübscher U
|
2000
|
Journal of molecular biology
|
Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis.
|
Hübscher U
|
1999
|
Journal of molecular biology
|
Intramolecular chimeras of the p51 subunit between HIV-1 and FIV reverse transcriptases suggest a stabilizing function for the p66 subunit in the heterodimeric enzyme.
|
Hübscher U
|
1999
|
Biochemistry
|
Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.
|
Hübscher U
|
1999
|
Chemistry & biology
|
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.
|
Hübscher U
|
1999
|
Nucleic acids research
|
Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon.
|
Hübscher U
|
1999
|
The Journal of biological chemistry
|
Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen.
|
Hübscher U
|
1998
|
The EMBO journal
|
Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1.
|
Hübscher U
|
1998
|
Oncogene
|
4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase.
|
Hübscher U
|
1998
|
Nucleic acids research
|
Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.
|
Hübscher U
|
1998
|
Journal of medicinal chemistry
|
The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering.
|
Hübscher U
|
1998
|
Journal of molecular biology
|
DNA ligase I selectively affects DNA synthesis by DNA polymerases delta and epsilon suggesting differential functions in DNA replication and repair.
|
Hübscher U
|
1998
|
The Journal of biological chemistry
|
Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen.
|
Hübscher U
|
1998
|
Biochem J
|
Mammalian base excision repair by DNA polymerases delta and epsilon.
|
Hübscher U
|
1998
|
Oncogene
|
Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases.
|
Hübscher U
|
1998
|
Journal of molecular biology
|
HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase.
|
Hübscher U
|
1997
|
AIDS (London, England)
|
Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).
|
Hübscher U
|
1997
|
Genomics
|
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions.
|
Hübscher U
|
1997
|
Journal of molecular biology
|
DNA polymerase delta, an essential enzyme for DNA transactions.
|
Hübscher U
|
1997
|
Biol Chem
|
Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: up-regulation of DNA polymerase delta.
|
Hübscher U
|
1997
|
Nucleic acids research
|
DNA replication machinery: functional characterization of a complex containing DNA polymerase alpha, DNA polymerase delta, and replication factor C suggests an asymmetric DNA polymerase dimer.
|
Hübscher U
|
1996
|
Biochemistry
|
Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet.
|
Hübscher U
|
1996
|
Nucleic acids research
|
Human Immunodeficiency Virus type 1 reverse transcriptase.
|
Hübscher U
|
1996
|
Biological chemistry Hoppe-Seyler
|
Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21.
|
Hübscher U
|
1995
|
Biochemistry
|
Production of active mouse DNA polymerase delta in bacteria.
|
Hübscher U
|
1995
|
Gene
|
DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene.
|
Hübscher U
|
1995
|
Proceedings of the National Academy of Sciences of the United States of America
|
The large subunit of HIV-1 reverse transcriptase interacts with beta-actin.
|
Hübscher U
|
1995
|
Nucleic acids research
|
Mammalian DNA nucleotide excision repair reconstituted with purified protein components.
|
Hübscher U
|
1995
|
Cell
|
Calf thymus Hsc70 protein protects and reactivates prokaryotic and eukaryotic enzymes.
|
Hübscher U
|
1995
|
The Journal of biological chemistry
|
Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns.
|
Hübscher U
|
1995
|
Proceedings of the National Academy of Sciences of the United States of America
|
Feline immunodeficiency virus reverse transcriptase: expression, functional characterization, and reconstitution of the 66- and 51-kilodalton subunits.
|
Hübscher U
|
1995
|
Journal of virology
|
Tyrosine 114 is essential for the trimeric structure and the functional activities of human proliferating cell nuclear antigen.
|
Hübscher U
|
1995
|
The EMBO journal
|
DNA polymerase delta holoenzyme: action on single-stranded DNA and on double-stranded DNA in the presence of replicative DNA helicases.
|
Hübscher U
|
1995
|
Biochemistry
|
DNA polymerase epsilon interacts with proliferating cell nuclear antigen in primer recognition and elongation.
|
Hübscher U
|
1995
|
Biochemistry
|
Nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA, RFC, and RPA.
|
Hübscher U
|
1995
|
Biochemistry
|
Mammalian DNA polymerase auxiliary proteins: analysis of replication factor C-catalyzed proliferating cell nuclear antigen loading onto circular double-stranded DNA.
|
Hübscher U
|
1995
|
Molecular and cellular biology
|
Assembly of DNA polymerase delta and epsilon holoenzymes depends on the geometry of the DNA template.
|
Hübscher U
|
1994
|
Nucleic acids research
|
Strand displacement activity of the human immunodeficiency virus type 1 reverse transcriptase heterodimer and its individual subunits.
|
Hübscher U
|
1994
|
The Journal of biological chemistry
|
DNA unwinding by replication protein A is a property of the 70 kDa subunit and is facilitated by phosphorylation of the 32 kDa subunit.
|
Hübscher U
|
1993
|
Nucleic acids research
|
A mammalian protein complex that repairs double-strand breaks and deletions by recombination.
|
Hübscher U
|
1993
|
The Journal of biological chemistry
|
Lagging strand DNA synthesis by calf thymus DNA polymerases alpha, beta, delta and epsilon in the presence of auxiliary proteins.
|
Hübscher U
|
1993
|
Nucleic acids research
|
Cloning of a mouse cDNA encoding DNA polymerase delta: refinement of the homology boxes.
|
Hübscher U
|
1993
|
Gene
|
Calf thymus RF-C as an essential component for DNA polymerase delta and epsilon holoenzymes function.
|
Hübscher U
|
1992
|
Nucleic acids research
|
DNA polymerase delta and epsilon holoenzymes from calf thymus.
|
Hübscher U
|
1992
|
Chromosoma
|
Developmental activity profile of DNA polymerases delta and alpha in rat neurons suggests a coordinated in vivo function.
|
Hübscher U
|
1992
|
In vivo (Athens, Greece)
|
DNA polymerase epsilon: in search of a function.
|
Hübscher U
|
1992
|
Trends in biochemical sciences
|
Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus.
|
Hübscher U
|
1991
|
The Journal of biological chemistry
|
Interaction of cis-diamminedichloroplatinum (II) with single-stranded DNA in the presence or absence of Escherichia coli single-stranded binding protein.
|
Hübscher U
|
1991
|
Biochemical pharmacology
|
Origin of adeno-associated virus DNA replication is a target of carcinogen-inducible DNA amplification.
|
Hübscher U
|
1991
|
Journal of virology
|
HP 0.35, a cephalosporin degradation product is a specific inhibitor of lentiviral RNAses H.
|
Hübscher U
|
1991
|
Nucleic acids research
|
The p15 carboxyl-terminal proteolysis product of the human immunodeficiency virus type 1 reverse transcriptase p66 has DNA polymerase activity.
|
Hübscher U
|
1991
|
Proceedings of the National Academy of Sciences of the United States of America
|
DNA helicase from calf thymus. Purification to apparent homogeneity and biochemical characterization of the enzyme.
|
Hübscher U
|
1990
|
The Journal of biological chemistry
|
Revised nomenclature for eukaryotic DNA polymerases.
|
Hübscher U
|
1990
|
Eur J Biochem
|
Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease.
|
Hübscher U
|
1990
|
FEBS letters
|
Eukaryotic DNA replication. Enzymes and proteins acting at the fork.
|
Hübscher U
|
1990
|
European journal of biochemistry / FEBS
|
Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development.
|
Hübscher U
|
1990
|
Mutation research
|
Calf thymus DNA polymerase delta independent of proliferating cell nuclear antigen (PCNA).
|
Hübscher U
|
1989
|
Nucleic acids research
|
Do DNA polymerases delta and alpha act coordinately as leading and lagging strand replicases?
|
Hübscher U
|
1988
|
FEBS letters
|
Sites of termination of in vitro DNA synthesis on cis-diamminedichloroplatinum(II) treated single-stranded DNA: a comparison between E. coli DNA polymerase I and eucaryotic DNA polymerases alpha.
|
Hübscher U
|
1988
|
Nucleic acids research
|
Calf thymus DNA polymerase delta: purification, biochemical and functional properties of the enzyme after its separation from DNA polymerase alpha, a DNA dependent ATPase and proliferating cell nuclear antigen.
|
Hübscher U
|
1988
|
Nucleic acids research
|
Replication of single-stranded porcine circovirus DNA by DNA polymerases alpha and delta.
|
Hübscher U
|
1988
|
Biochimica et biophysica acta
|
Calcium-dependent calmodulin-binding proteins associated with mammalian DNA polymerase alpha.
|
Hübscher U
|
1988
|
Biochimica et biophysica acta
|
Mammalian DNA polymerase alpha: a replication-competent holoenzyme form from calf thymus.
|
Hübscher U
|
1987
|
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
|
Current understanding of UV-induced base pair substitution mutation in E. coli with particular reference to the DNA polymerase III complex.
|
Hübscher U
|
1987
|
Mutation research
|
Betalactam antibiotics interfere with eukaryotic DNA-replication by inhibiting DNA polymerase alpha.
|
Hübscher U
|
1987
|
Nucleic acids research
|
Mammalian DNA polymerase alpha: a replication competent holoenzyme form from calf thymus.
|
Hübscher U
|
1987
|
Nucleic acids research
|
Cloning and expression of a cDNA encoding a catalytically active fragment of calf thymus DNA polymerase alpha.
|
Hübscher U
|
1986
|
Biochemical and biophysical research communications
|
Mammalian DNA helicase.
|
Hübscher U
|
1985
|
Nucleic acids research
|
Mammalian DNA polymerase alpha holoenzyme.
|
Hübscher U
|
1984
|
Adv Exp Med Biol
|
Mammalian DNA polymerase alpha holoenzymes with possible functions at the leading and lagging strand of the replication fork.
|
Hübscher U
|
1984
|
Proceedings of the National Academy of Sciences of the United States of America
|
The mammalian primase is part of a high molecular weight DNA polymerase alpha polypeptide.
|
Hübscher U
|
1983
|
The EMBO journal
|
Structural homology among calf thymus alpha-polymerase polypeptides.
|
Hübscher U
|
1982
|
Nucleic acids research
|
A mammalian DNA polymerase alpha holoenzyme functioning on defined in vivo-like templates.
|
Hübscher U
|
1982
|
The EMBO journal
|
Evidence that a high molecular weight replicative DNA polymerase is conserved during evolution.
|
Hübscher U
|
1981
|
Proceedings of the National Academy of Sciences of the United States of America
|
The dnaZ protein, the gamma subunit of DNA polymerase III holoenzyme of Escherichia coli.
|
Hübscher U
|
1980
|
The Journal of biological chemistry
|
Functions of DNA polymerases alpha, beta, and gamma in neurons during development.
|
Hübscher U
|
1979
|
Cold Spring Harbor symposia on quantitative biology
|
The delta subunit of Escherichia coli DNA polymerase III holoenzyme is the dnaX gene product.
|
Hübscher U
|
1979
|
Proceedings of the National Academy of Sciences of the United States of America
|
Functional roles of DNA polymerases beta and gamma.
|
Hübscher U
|
1979
|
Proceedings of the National Academy of Sciences of the United States of America
|
DNA polymerase beta from brain neurons is a repair enzyme.
|
Hübscher U
|
1979
|
European journal of biochemistry / FEBS
|
Identity of DNA polymerase gamma from synaptosomal mitochondria and rat-brain nuclei.
|
Hübscher U
|
1977
|
European journal of biochemistry / FEBS
|
Variation of DNA polymerases-alpha, -beta. and -gamma during perinatal tissue growth and differentiation.
|
Hübscher U
|
1977
|
Nucleic acids research
|