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Blanco L

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Publications:

Title Authors Year Journal
Cloning and expression of gene 2, required for the protein-primed initiation of the Bacillus subtilis phage phi 29 DNA replication. Blanco L Gene
Increased Learning and Brain Long-Term Potentiation in Aged Mice Lacking DNA Polymerase μ. Blanco L 2013 PloS one
Yeast pol4 promotes tel1-regulated chromosomal translocations. Blanco L 2013 PLoS genetics
Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase. Blanco L 2013 Cell reports
PrimPol, an Archaic Primase/Polymerase Operating in Human Cells. Blanco L 2013 Molecular cell
DNA expansions generated by human Polμ on iterative sequences. Blanco L 2012 Nucleic acids research
Ribonucleotides and manganese ions improve non-homologous end joining by human Polμ Blanco L 2012 Nucleic acids research
Molecular architecture of a multifunctional MCM complex. Blanco L 2011 Nucleic acids research
Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase. Blanco L 2011 Molecular cell
The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway. Blanco L 2010 Carcinogenesis
Improvement of phi29 DNA polymerase amplification performance by fusion of DNA binding motifs. Blanco L 2010 Proceedings of the National Academy of Sciences of the United States of America
Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ. Blanco L 2009 Proceedings of the National Academy of Sciences of the United States of America
Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair. Blanco L 2009 PLoS Genet
A role for DNA polymerase mu in the emerging DJH rearrangements of the postgastrulation mouse embryo. Blanco L 2009 Molecular and cellular biology
Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. Blanco L 2009 PloS one
The bacteriophage phi29 DNA polymerase. Blanco L 2008 IUBMB Life
Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts. Blanco L 2008 Nucleic acids research
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases. Blanco L 2007 The EMBO journal
Human DNA polymerase lambda is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine. Blanco L 2007 DNA repair
Structure and function of a mycobacterial NHEJ DNA repair polymerase. Blanco L 2007 Journal of molecular biology
An intrinsic 5'-deoxyribose-5-phosphate lyase activity in DNA polymerase beta from Leishmania infantum supports a role in DNA repair. Blanco L 2006 DNA repair
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. Blanco L 2006 The EMBO journal
Promiscuous mismatch extension by human DNA polymerase lambda. Blanco L 2006 Nucleic acids research
A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis. Blanco L 2006 Nucleic acids research
A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Blanco L 2005 Molecular cell
Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts. Blanco L 2005 European journal of immunology
Comparison of functional properties of mammalian DNA polymerase lambda and DNA polymerase beta in reactions of DNA synthesis related to DNA repair. Blanco L 2005 Biochimica et biophysica acta
Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe. Blanco L 2005 Nucleic acids research
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. Blanco L 2005 Proceedings of the National Academy of Sciences of the United States of America
Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. Blanco L 2004 The Journal of biological chemistry
Aphidicolin-resistant and -sensitive base excision repair in wild-type and DNA polymerase beta-defective mouse cells. Blanco L 2004 DNA repair
A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Blanco L 2004 Molecular cell
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. Blanco L 2004 Molecular cell
Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate. Blanco L 2004 Nucleic acids research
Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity. Blanco L 2004 The Journal of biological chemistry
Lack of sugar discrimination by human Pol mu requires a single glycine residue. Blanco L 2003 Nucleic acids research
Solution structure of the lyase domain of human DNA polymerase lambda. Blanco L 2003 Biochemistry
phi 29 DNA polymerase residue Leu384, highly conserved in motif B of eukaryotic type DNA replicases, is involved in nucleotide insertion fidelity. Blanco L 2003 The Journal of biological chemistry
Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions. Blanco L 2003 Journal of molecular biology
Are there mutator polymerases? Blanco L 2003 ScientificWorldJournal
DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA. Blanco L 2003 Journal of molecular biology
The frameshift infidelity of human DNA polymerase lambda. Implications for function. Blanco L 2003 The Journal of biological chemistry
Human DNA polymerase mu (Pol mu) exhibits an unusual replication slippage ability at AAF lesion. Blanco L 2002 Nucleic acids research
DNA polymerase lambda, a novel DNA repair enzyme in human cells. Blanco L 2002 The Journal of biological chemistry
A positively charged residue of phi29 DNA polymerase, highly conserved in DNA polymerases from families A and B, is involved in binding the incoming nucleotide. Blanco L 2002 Nucleic acids research
A highly conserved lysine residue in phi29 DNA polymerase is important for correct binding of the templating nucleotide during initiation of phi29 DNA replication. Blanco L 2002 Journal of molecular biology
Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. Blanco L 2002 The Journal of biological chemistry
DNA polymerase mu, a candidate hypermutase? Blanco L 2001 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Eukaryotic DNA polymerases: proposal for a revised nomenclature. Blanco L 2001 The Journal of biological chemistry
Nuclear DNA polymerase beta from Leishmania infantum. Cloning, molecular analysis and developmental regulation. Blanco L 2001 Nucleic acids research
Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. Blanco L 2001 The Journal of biological chemistry
DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. Blanco L 2000 The EMBO journal
DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis. Blanco L 2000 Journal of molecular biology
An aspartic acid residue in TPR-1, a specific region of protein-priming DNA polymerases, is required for the functional interaction with primer terminal protein. Blanco L 2000 Journal of molecular biology
Analysis of O29 DNA polymerase by partial proteolysis: binding of terminal protein in the double-stranded DNA channel. Blanco L 2000 Journal of molecular biology
Processive proofreading and the spatial relationship between polymerase and exonuclease active sites of bacteriophage phi29 DNA polymerase. Blanco L 1999 Journal of molecular biology
A single tyrosine prevents insertion of ribonucleotides in the eukaryotic-type phi29 DNA polymerase. Blanco L 1999 Journal of molecular biology
Phage phi29 terminal protein residues Asn80 and Tyr82 are recognition elements of the replication origins. Blanco L 1999 The Journal of biological chemistry
Role of the "YxGG/A" motif of Phi29 DNA polymerase in protein-primed replication. Blanco L 1999 Journal of molecular biology
Phi 29 DNA polymerase requires the N-terminal domain to bind terminal protein and DNA primer substrates. Blanco L 1998 Journal of molecular biology
DNA polymerase template switching at specific sites on the phi29 genome causes the in vivo accumulation of subgenomic phi29 DNA molecules. Blanco L 1998 Molecular microbiology
phi29 DNA polymerase residue Ser122, a single-stranded DNA ligand for 3'-5' exonucleolysis, is required to interact with the terminal protein. Blanco L 1998 The Journal of biological chemistry
Mutational analysis of phi29 DNA polymerase residues acting as ssDNA ligands for 3'-5' exonucleolysis. Blanco L 1998 Journal of molecular biology
Role of the first aspartate residue of the "YxDTDS" motif of phi29 DNA polymerase as a metal ligand during both TP-primed and DNA-primed DNA synthesis. Blanco L 1998 Journal of molecular biology
The RGD sequence in phage phi29 terminal protein is required for interaction with phi29 DNA polymerase. Blanco L 1998 Virology
o29 DNA polymerase residue Lys383, invariant at motif B of DNA-dependent polymerases, is involved in dNTP binding. Blanco L 1997 Journal of molecular biology
Characterization of an African swine fever virus 20-kDa DNA polymerase involved in DNA repair. Blanco L 1997 The Journal of biological chemistry
Processive proofreading by the adenovirus DNA polymerase. Association with the priming protein reduces exonucleolytic degradation. Blanco L 1997 Nucleic acids research
Protein-primed DNA replication: a transition between two modes of priming by a unique DNA polymerase. Blanco L 1997 The EMBO journal
In vitro evolution of terminal protein-containing genomes. Blanco L 1997 Proceedings of the National Academy of Sciences of the United States of America
An invariant lysine residue is involved in catalysis at the 3'-5' exonuclease active site of eukaryotic-type DNA polymerases. Blanco L 1997 Journal of molecular biology
Relating structure to function in phi29 DNA polymerase. Blanco L 1996 The Journal of biological chemistry
A DNA binding motif coordinating synthesis and degradation in proofreading DNA polymerases. Blanco L 1996 The EMBO journal
Functional characterization of the genes coding for the terminal protein and DNA polymerase from bacteriophage GA-1. Evidence for a sliding-back mechanism during protein-primed GA-1 DNA replication. Blanco L 1996 Journal of molecular biology
Primer-terminus stabilization at the 3'-5' exonuclease active site of phi29 DNA polymerase. Involvement of two amino acid residues highly conserved in proofreading DNA polymerases. Blanco L 1996 The EMBO journal
Primer terminus stabilization at the phi 29 DNA polymerase active site. Mutational analysis of conserved motif KXY. Blanco L 1995 The Journal of biological chemistry
Mutational analysis of bacteriophage phi 29 DNA polymerase. Blanco L 1995 Methods in enzymology
Protein-nucleic acid interactions in bacteriophage phi 29 DNA replication. Blanco L 1995 FEMS microbiology reviews
Purification of bacteriophage phi 29 DNA polymerase. Blanco L 1995 Methods in enzymology
A novel kinetic analysis to calculate nucleotide affinity of proofreading DNA polymerases. Application to phi 29 DNA polymerase fidelity mutants. Blanco L 1995 The Journal of biological chemistry
3'-->5' exonuclease active site of phi 29 DNA polymerase. Evidence favoring a metal ion-assisted reaction mechanism. Blanco L 1994 The Journal of biological chemistry
Terminal protein-primed DNA amplification. Blanco L 1994 Proceedings of the National Academy of Sciences of the United States of America
Primer-terminus stabilization at the psi 29 DNA polymerase active site. Mutational analysis of conserved motif TX2GR. Blanco L 1994 The Journal of biological chemistry
Phi 29 DNA polymerase active site. Residue ASP249 of conserved amino acid motif "Dx2SLYP" is critical for synthetic activities. Blanco L 1993 The Journal of biological chemistry
In vitro replication of bacteriophage PRD1 DNA. Characterization of the protein-primed initiation site. Blanco L 1993 Nucleic acids research
Fidelity of phi 29 DNA polymerase. Comparison between protein-primed initiation and DNA polymerization. Blanco L 1993 The Journal of biological chemistry
Phi 29 DNA polymerase active site. The conserved amino acid motif "Kx3NSxYG" is involved in template-primer binding and dNTP selection. Blanco L 1993 The Journal of biological chemistry
Site-directed mutagenesis at the Exo III motif of phi 29 DNA polymerase; overlapping structural domains for the 3'-5' exonuclease and strand-displacement activities. Blanco L 1992 The EMBO journal
Metal activation of synthetic and degradative activities of phi 29 DNA polymerase, a model enzyme for protein-primed DNA replication. Blanco L 1992 Biochemistry
DNA-independent deoxynucleotidylation of the phi 29 terminal protein by the phi 29 DNA polymerase. Blanco L 1992 The Journal of biological chemistry
Evidence favouring the hypothesis of a conserved 3'-5' exonuclease active site in DNA-dependent DNA polymerases. Blanco L 1992 Gene
In vitro replication of bacteriophage PRD1 DNA. Metal activation of protein-primed initiation and DNA elongation. Blanco L 1992 Nucleic acids research
Initiation of phi 29 DNA replication occurs at the second 3' nucleotide of the linear template: a sliding-back mechanism for protein-primed DNA replication. Blanco L 1992 Proceedings of the National Academy of Sciences of the United States of America
The bacteriophage phi 29 DNA polymerase, a proofreading enzyme. Blanco L 1992 The Journal of biological chemistry
Structural and functional studies on phi 29 DNA polymerase. Blanco L 1992 Chromosoma
Phi 29 DNA polymerase active site. Mutants in conserved residues Tyr254 and Tyr390 are affected in dNTP binding. Blanco L 1992 The Journal of biological chemistry
A general structure for DNA-dependent DNA polymerases. Blanco L 1991 Gene
MIP1 DNA polymerase of S. cerevisiae: structural similarity with the E. coli DNA polymerase I-type enzymes. Blanco L 1991 Nucleic acids research
Characterization and mapping of the pyrophosphorolytic activity of the phage phi 29 DNA polymerase. Involvement of amino acid motifs highly conserved in alpha-like DNA polymerases. Blanco L 1991 The Journal of biological chemistry
Structural and functional analysis of temperature-sensitive mutants of the phage phi 29 DNA polymerase. Blanco L 1990 Nucleic acids research
The highly conserved amino acid sequence motif Tyr-Gly-Asp-Thr-Asp-Ser in alpha-like DNA polymerases is required by phage phi 29 DNA polymerase for protein-primed initiation and polymerization. Blanco L 1990 Proceedings of the National Academy of Sciences of the United States of America
Site-directed mutagenesis of the YCDTDS amino acid motif of the phi 29 DNA polymerase. Blanco L 1990 Gene
Highly efficient DNA synthesis by the phage phi 29 DNA polymerase. Symmetrical mode of DNA replication. Blanco L 1989 The Journal of biological chemistry
A conserved 3'----5' exonuclease active site in prokaryotic and eukaryotic DNA polymerases. Blanco L 1989 Cell
Structural and functional relationships between prokaryotic and eukaryotic DNA polymerases. Blanco L 1987 The EMBO journal
Effect of NH4+ ions on phi 29 DNA-protein p3 replication: formation of a complex between the terminal protein and the DNA polymerase. Blanco L 1987 J Virol
Effect of aphidicolin and nucleotide analogs on the phage phi 29 DNA polymerase. Blanco L 1986 Virology
Replication of phage phi 29 DNA in vitro: role of the viral protein p6 in initiation and elongation. Blanco L 1986 Nucleic acids research
Characterization of a 3'----5' exonuclease activity in the phage phi 29-encoded DNA polymerase. Blanco L 1985 Nucleic acids research
Replication of phage phi 29 DNA with purified terminal protein and DNA polymerase: synthesis of full-length phi 29 DNA. Blanco L 1985 Proceedings of the National Academy of Sciences of the United States of America
Overproduction and purification of protein P6 of Bacillus subtilis phage phi 29: role in the initiation of DNA replication. Blanco L 1985 Nucleic acids research
Characterization and purification of a phage phi 29-encoded DNA polymerase required for the initiation of replication. Blanco L 1984 Proceedings of the National Academy of Sciences of the United States of America
Factors involved in the initiation of phage phi 29 DNA replication in vitro: requirement of the gene 2 product for the formation of the protein p3-dAMP complex. Blanco L 1983 Nucleic acids research
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