T7

From bacteriophage T7 (aliases:T7 DNA polymerase, phage T7)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for T7.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

T7 is a family A enzyme from bacteriophage T7.

Selected Properties for T7:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (13) Yes (2) 3.7e-07-1.5e-03 errors/bp (3) 2.2e-06-4.5e-02 errors/bp (4) 2.6e-07-6.7e-06 errors/bp (2)
Year Authors Title Results by property
2017 TP Hoekstra, M Depken, SN Lin, J Cabanas-Danés, P Gross, RT Dame, EJ Peterman, GJ Wuite Switching between Exonucleolysis and ...
2013 Leena Maddukuri, Sarah C Shuck, Robert Lawton Eoff, Linlin Zhao, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett Replication, Repair and Translesion P... Template lesions,All properties
2013 Barak Akabayov, Sabine R Akabayov, Seung-Joo Lee, Gerhard Wagner, Charles C Richardson Impact of macromolecular crowding on ...
2012 Ngoc Quang Tran, Seung-Joo Lee, Barak Akabayov, Donald E Johnson, Charles C Richardson Thioredoxin, the Processivity Factor,...
2012 Arkadiusz W Kulczyk, Barak Akabayov, Seung-Joo Lee, Mihnea Bostina, Steven A Berkowitz, Charles C Richardson An Interaction between DNA Polymerase... Other accessory protein(s),All properties
2012 Arkadiusz W Kulczyk, Charles C Richardson Molecular interactions in the priming...
2011 Gayatri Patel, Daniel S Johnson, Bo Sun, Manjula Pandey, Xiong Yu, Edward H Egelman, Michelle D Wang, Smita S Patel A257T linker region mutant of T7 heli...
2011 Zhinan Jin, Kenneth A Johnson Role of a GAG hinge in the nucleotide...
2011 M Hogg, AE Sauer-Eriksson, Erik Johansson Promiscuous DNA synthesis by human DN...
2011 Vladimir V Didenko In situ labeling of DNA breaks and ap...
2011 B Zhu, Seung-Joo Lee, Charles C Richardson Bypass of a nick by the replisome of ... Nucleotide incorporation accessory protein(s),All properties
2011 Katrin Viikov, Priit Väljamäe, Juhan Sedman Yeast mitochondrial DNA polymerase is... Processivity,Strand Displacement,All properties
2011 Huidong Zhang, Seung-Joo Lee, B Zhu, Ngoc Quang Tran, Stanley Tabor, Charles C Richardson Helicase-DNA polymerase interaction i...
2010 Candice M Etson, Samir M Hamdan, Charles C Richardson, Antoine M van Oijen Thioredoxin suppresses microscopic ho...
2010 Ajit K Satapathy, Anna B Kochaniak, Sourav Mukherjee, DJ Crampton, Antoine M van Oijen, Charles C Richardson Residues in the central beta-hairpin ...
2010 Barak Akabayov, Sabine R Akabayov, Seung-Joo Lee, Stanley Tabor, Arkadiusz W Kulczyk, Charles C Richardson Conformational dynamics of bacterioph...
2010 Linda J Reha-Krantz DNA polymerase proofreading: Multiple...
2010 Felix Olasagasti, Kate R Lieberman, Seico Benner, Gerald M Cherf, Joseph M Dahl, David W Deamer, Mark Akeson Replication of individual DNA molecul...
2009 Huidong Zhang, Urban Bren, Ivan D Kozekov, Carmelo J Rizzo, Donald F Stec, F Peter Guengerich Steric and electrostatic effects at t...
2009 Seung-Joo Lee, Kajal Chowdhury, Stanley Tabor, Charles C Richardson Rescue of bacteriophage T7 DNA polyme...
2009 Liming Wang, Suse Broyde, Yongqing Zhang Polymerase-tailored variations in the...
2009 Yu-Chih Tsai, Zhinan Jin, Kenneth A Johnson Site-specific labeling of T7 DNA poly...
2009 Sharmistha Ghosh, Boriana Marintcheva, Masateru Takahashi, Charles C Richardson C-terminal phenylalanine of bacteriop...
2009 Kiyonobu Karata, Antonio E Vidal, Roger Woodgate Construction of a circular single-str...
2009 Boriana Marintcheva, Udi Qimron, Yao Yu, Stanley Tabor, Charles C Richardson, Charles C Richardson Mutations in the gene 5 DNA polymeras...
2009 Brett Gyarfas, Felix Olasagasti, Seico Benner, Daniel R Garalde, Kate R Lieberman, Mark Akeson Mapping the position of DNA polymeras...
2008 Sharmistha Ghosh, Samir M Hamdan, Timothy E Cook, Charles C Richardson Interactions of Escherichia coli thio...
2008 Lakshminarayan M Iyer, Saraswathi Abhiman, L Aravind A new family of polymerases related t...
2008 Ngoc Quang Tran, Lisa F Rezende, Udi Qimron, Charles C Richardson, Stanley Tabor Gene 1.7 of bacteriophage T7 confers ...
2008 Michael D Scholle, Bridget S Banach, Samir M Hamdan, Charles C Richardson, Brian K Kay Peptide ligands specific to the oxidi...
2008 Linda J Reha-Krantz Recent patents of gene sequences rela...
2007 Donald E Johnson, Masateru Takahashi, Samir M Hamdan, Seung-Joo Lee, Charles C Richardson Exchange of DNA polymerases at the re...
2007 Samir M Hamdan, Donald E Johnson, Nathan A Tanner, Jong-Bong Lee, Udi Qimron, Stanley Tabor, Antoine M van Oijen, Charles C Richardson Dynamic DNA helicase-DNA polymerase i...
2007 Guobin Luo, Michael Wang, William H Konigsberg, X Sunney Xie Single-molecule and ensemble fluoresc...
2007 Vincent J Cannistraro, John-Stephen Taylor Ability of polymerase eta and T7 DNA ...
2007 Christian Castro, Eric D Smidansky, Kenneth R Maksimchuk, Jamie J Arnold, Victoria S Korneeva, Matthias Götte, William H Konigsberg, Craig E Cameron Two proton transfers in the transitio...
2006 Boriana Marintcheva, Samir M Hamdan, Seung-Joo Lee, Charles C Richardson Essential residues in the C terminus ...
2006 Ichiro Hirao, Michiko Kimoto, Tsuneo Mitsui, Tsuyoshi Fujiwara, Rie Kawai, Akira Sato, Yoko Harada, Shigeyuki Yokoyama An unnatural hydrophobic base pair sy...
2006 Scott D McCulloch, Thomas A Kunkel Multiple solutions to inefficient les...
2006 Seung-Joo Lee, Boriana Marintcheva, Samir M Hamdan, Charles C Richardson The C-terminal residues of bacterioph...
2006 Joyce Chiu, Daniel Tillett, Paul E March Mutation of Phe102 to Ser in the carb...
2006 Joyce Chiu, Daniel Tillett, Paul E March Coexpression of the subunits of T7 DN...
2006 Yu-Chih Tsai, Kenneth A Johnson A new paradigm for DNA polymerase spe...
2006 Tae Woo Kim, Luis G Brieba, Tom Ellenberger, Eric T Kool Functional evidence for a small and r...
2005 Hong Zang, Thomas M Harris, F Peter Guengerich Kinetics of nucleotide incorporation ...
2005 Samir M Hamdan, Boriana Marintcheva, Timothy E Cook, Seung-Joo Lee, Stanley Tabor, Charles C Richardson A unique loop in T7 DNA polymerase me...
2005 William A Beard, Samuel H Wilson Syn-full behavior by T7 DNA polymerase.
2005 Matthew Hogg, Susan S Wallace, Sylvie Doublié Bumps in the road: how replicative DN...
2005 Jan Florián, Myron F Goodman, Arieh Warshel Computer simulations of protein funct...
2005 Luis G Brieba, Robert J Kokoska, Katarzyna Bebenek, Thomas A Kunkel, Tom Ellenberger A lysine residue in the fingers subdo...
2005 Seung-Joo Lee, Charles C Richardson Acidic residues in the nucleotide-bin...
2005 Hong Zang, Thomas M Harris, F Peter Guengerich Kinetics of nucleotide incorporation ...
2005 Marina Schlicke, Susanne Brakmann Expression and purification of histid...
2004 Jaya K Kumar, Erica T Chiu, Stanley Tabor, Charles C Richardson A unique region in bacteriophage t7 D...
2004 Vincent J Cannistraro, John-Stephen Taylor DNA-thumb interactions and processivi...
2004 Kevin A Fiala, Zucai Suo Pre-steady-state kinetic studies of t... Overall Error Rate,All properties
2004 Luis G Brieba, Brandt F Eichman, Robert J Kokoska, Sylvie Doublié, Thomas A Kunkel, Tom Ellenberger Structural basis for the dual coding ...
2004 Yingqian Li, Shuchismita Dutta, Sylvie Doublié, Hussam Moh'd Bdour, John-Stephen Taylor, Tom Ellenberger Nucleotide insertion opposite a cis-s...
2004 Masato Kato, Takuhiro Ito, Gerhard Wagner, Tom Ellenberger A molecular handoff between bacteriop...
2004 Shuchismita Dutta, Yingqian Li, Donald E Johnson, Leonid Dzantiev, Charles C Richardson, Louis J Romano, Tom Ellenberger Crystal structures of 2-acetylaminofl...
2004 DJ Crampton, S Guo, Donald E Johnson, Charles C Richardson The arginine finger of bacteriophage ...
2003 Netai C Singha, Alexios Vlamis-Gardikas, Arne Holmgren Real-time kinetics of the interaction...
2003 Natasha Paul, Vishal C Nashine, Geoffrey Hoops, Peiming Zhang, Jie Zhou, Donald E Bergstrom, V Jo Davisson DNA polymerase template interactions ...
2003 Robert E Johnson, José Trincao, Aneel K Aggarwal, Satya Prakash, Louise Prakash Deoxynucleotide triphosphate binding ...
2003 Zheng-Guo He, Lisa F Rezende, Smaranda Willcox, Jack D Griffith, Charles C Richardson The carboxyl-terminal domain of bacte...
2003 Lisa F Rezende, Smaranda Willcox, Jack D Griffith, Charles C Richardson A single-stranded DNA-binding protein...
2003 Edel M Hyland, Lisa F Rezende, Charles C Richardson The DNA binding domain of the gene 2....
2003 William A Beard, Samuel H Wilson Structural insights into the origins ...
2003 Ichiro Hirao, Tsuneo Mitsui, Michiko Kimoto, Yoko Harada, Shigeyuki Yokoyama An unnatural base pair for efficient ...
2002 Adrienne M Woodside, F Peter Guengerich Misincorporation and stalling at O(6)...
2002 Joonsoo Lee, Paul D Chastain, Jack D Griffith, Charles C Richardson Lagging strand synthesis in coordinat...
2002 Lisa F Rezende, Thomas Hollis, Tom Ellenberger, Charles C Richardson Essential amino acid residues in the ...
2002 Cuihua Liu, Craig T Martin Promoter clearance by T7 RNA polymera...
2002 Adrienne M Woodside, F Peter Guengerich Effect of the O6 substituent on misin...
2001 Jaya K Kumar, R Kremsdorf, Stanley Tabor, Charles C Richardson A Mutation in the gene-encoding bacte...
2001 Graciella Andrei, Pierre Fiten, Erik De Clercq, Robert Snoeck, Ghislain Opdenakker Evaluating phenotype and genotype of ...
2001 Emmanuelle Delagoutte, Peter H von Hippel Molecular mechanisms of the functiona...
2001 Thomas Hollis, J M Stattel, D S Walther, Charles C Richardson, Tom Ellenberger Structure of the gene 2.5 protein, a ...
2001 Farid A Kadyrov, John W Drake Conditional coupling of leading-stran...
2001 T C Lin, C X Wang, Catherine M Joyce, William H Konigsberg 3'-5' Exonucleolytic activity of DNA ...
2001 R A Perlow, Suse Broyde Evading the proofreading machinery of...
2000 G J Wuite, Steven B Smith, M Young, D Keller, Carlos Bustamante Single-molecule studies of the effect... Full length or truncated,Processivity,3-5' exo,Vmax,All properties
2000 T Y Tseng, David N Frick, Charles C Richardson Characterization of a novel DNA prima...
2000 L M Wentzell, A Maxwell The complex of DNA gyrase and quinolo...
2000 Kajal Chowdhury, Stanley Tabor, Charles C Richardson A unique loop in the DNA-binding crev...
2000 L Sun, Michael Wang, Eric T Kool, John-Stephen Taylor Pyrene nucleotide as a mechanistic pr...
1999 Miguel de Vega, Luis Blanco, Margarita Salas Processive proofreading and the spati... 3-5' exo,All properties
1999 D Canceill, Enrique Viguera, S Dusko Ehrlich Replication slippage of different DNA...
1999 S Guo, Stanley Tabor, Charles C Richardson The linker region between the helicas...
1999 Zucai Suo, S J Lippard, Kenneth A Johnson Single d(GpG)/cis-diammineplatinum(II...
1998 S W Graves, Allison A Johnson, Kenneth A Johnson Expression, purification, and initial... Processivity,Kd,Vmax,All properties
1998 M Falkenberg, P Elias, I. Robert Lehman The herpes simplex virus type 1 helic...
1998 P Keohavong, R Shukla, A Melacrinos, B W Day, Linda J Reha-Krantz Effects of bulky polycyclic aromatic ...
1998 F Hill, David Loakes, D M Brown Polymerase recognition of synthetic o...
1998 K Park, Zeger Debyser, Stanley Tabor, Charles C Richardson, Jack D Griffith Formation of a DNA loop at the replic...
1998 Sylvie Doublié, Tom Ellenberger The mechanism of action of T7 DNA pol...
1998 David N Frick, K Baradaran, Charles C Richardson An N-terminal fragment of the gene 4 ...
1998 D Kong, Charles C Richardson Role of the acidic carboxyl-terminal ...
1998 Sylvie Doublié, Stanley Tabor, A M Long, Charles C Richardson, Tom Ellenberger Crystal structure of a bacteriophage ...
1998 L L Furge, F Peter Guengerich Pre-steady-state kinetics of nucleoti...
1998 Zucai Suo, Kenneth A Johnson Selective inhibition of HIV-1 reverse...
1997 X M Yang, Charles C Richardson Amino acid changes in a unique sequen... Full length or truncated,Processivity,All properties
1997 S M Notarnicola, H L Mulcahy, Joonsoo Lee, Charles C Richardson The acidic carboxyl terminus of the b...
1997 E Bedford, Stanley Tabor, Charles C Richardson The thioredoxin binding domain of bac... Specific Activity,Processivity,3-5' exo,All properties
1997 T Kusakabe, Charles C Richardson Gene 4 DNA primase of bacteriophage T...
1996 J W Brandis, S G Edwards, Kenneth A Johnson Slow rate of phosphodiester bond form...
1996 F B Perler, Sandeep Kumar, H Kong Thermostable DNA polymerases. Full length or truncated,3-5' exo,Vmax,All properties
1996 S Wiemann, A Schilke, S Rechmann, J Zimmermann, H Voss, W Ansorge Reducing "double sequences" in automa...
1996 J S Himawan, Charles C Richardson Amino acid residues critical for the ...
1995 Stanley Tabor, Charles C Richardson A single residue in DNA polymerases o...
1995 M N Rigler, Louis J Romano Differences in the mechanism of stimu...
1994 M J Donlin, Kenneth A Johnson Mutants affecting nucleotide recognit...
1994 M Bodescot, O Brison T7 DNA polymerase requires unusual re...
1994 M Bodescot, O Brison Efficient second-strand cDNA synthesi...
1994 Thomas A Kunkel, Smita S Patel, Kenneth A Johnson Error-prone replication of repeated D... Cloned or native,Tagged,Full length or truncated,3-5' exo,5-3' exo,Frameshift Error Rate,Nucleotide Substitution Rate,Nucleotide incorporation accessory protein(s),All properties
1994 Zeger Debyser, Stanley Tabor, Charles C Richardson Coordination of leading and lagging s...
1994 M Thakar, A Bilenko, W J Becktel Osmolyte mediation of T7 DNA polymera...
1994 J E Lindsley, Robert P P Fuchs Use of single-turnover kinetics to st...
1994 J Ji, Jean-Sébastien Hoffmann, L Loeb Mutagenicity and pausing of HIV rever...
1994 L C Bridgewater, F C Manning, E S Woo, Steven R Patierno DNA polymerase arrest by adducted tri...
1993 H Kong, R B Kucera, William E Jack Characterization of a DNA polymerase ... Processivity,KM,All properties
1993 S M Wurgler, Charles C Richardson DNA binding properties of the deoxygu...
1993 D R Koehler, P C Hanawalt Digestion of damaged DNA by the T7 DN...
1992 J S Himawan, Charles C Richardson Genetic analysis of the interaction b...
1992 Carl W Fuller Modified T7 DNA polymerase for DNA se...
1992 L G Lee, C R Connell, S L Woo, R D Cheng, B F McArdle, Carl W Fuller, N D Halloran, R K Wilson DNA sequencing with dye-labeled termi...
1992 Y T Kim, Stanley Tabor, J E Churchich, Charles C Richardson Interactions of gene 2.5 protein and ...
1992 DNA Replication
1991 I Wong, Smita S Patel, Kenneth A Johnson An induced-fit kinetic mechanism for ...
1991 I Slaby, A Holmgren Rapid isolation of homogeneous cloned...
1991 Smita S Patel, I Wong, Kenneth A Johnson Pre-steady-state kinetic analysis of ... Cloned or native,Full length or truncated,Processivity,3-5' exo,KM,Kd,Vmax,All properties
1991 P Mattila, J Korpela, T Tenkanen, K Pitkänen Fidelity of DNA synthesis by the Ther... 3-5' exo,Frameshift Error Rate,Nucleotide Substitution Rate,All properties
1991 M J Donlin, Smita S Patel, Kenneth A Johnson Kinetic partitioning between the exon...
1990 B S Strauss, Jianhong Wang Role of DNA polymerase 3'----5' exonu...
1990 Stanley Tabor, Charles C Richardson DNA sequence analysis with a modified...
1990 D B Reardon, C A Bigger, A Dipple DNA polymerase action on bulky deoxyg...
1989 Stanley Tabor, Charles C Richardson Selective inactivation of the exonucl...
1989 Stanley Tabor, Charles C Richardson Effect of manganese ions on the incor...
1989 Katarzyna Bebenek, Thomas A Kunkel The use of native T7 DNA polymerase f...
1989 I Slaby, A Holmgren Thioredoxin reductase-dependent insul...
1989 J Sahm, E Turkington, D LaPointe, Bernard Strauss Mutation induced in vitro on a C-8 gu...
1989 J A Bernstein, Charles C Richardson Characterization of the helicase and ...
1988 T Z Su, M R el-Gewely A multisite-directed mutagenesis usin...
1988 S D Rabkin, Charles C Richardson Initiation of DNA replication at clon...
1988 T W Myers, Louis J Romano Mechanism of stimulation of T7 DNA po...
1988 H Nakai, Charles C Richardson The effect of the T7 and Escherichia ...
1987 H E Huber, Stanley Tabor, Charles C Richardson Escherichia coli thioredoxin stabiliz...
1987 Stanley Tabor, Charles C Richardson Selective oxidation of the exonucleas...
1987 Stanley Tabor, Charles C Richardson DNA sequence analysis with a modified...
1987 Stanley Tabor, H E Huber, Charles C Richardson Escherichia coli thioredoxin confers ... Cloned or native,Tagged,Full length or truncated,Specific Activity,Processivity,Vmax,All properties
1986 H Nakai, Charles C Richardson Interactions of the DNA polymerase an...
1986 M L Michaels, M S Lee, Louis J Romano Contrasting effects of Escherichia co...
1985 C W Fuller, Charles C Richardson Initiation of DNA replication at the ...
1985 C W Fuller, Charles C Richardson Initiation of DNA replication at the ...
1985 Stanley Tabor, Charles C Richardson A bacteriophage T7 RNA polymerase/pro...
1984 I Slaby, B Lind, A Holmgren T7 DNA polymerase is not a zinc-metal...
1983 S Adler, P Modrich T7-induced DNA polymerase. Requiremen... Cloned or native,Tagged,Full length or truncated,Specific Activity,3-5' exo,Molecular Weight,3-5' Exo Specific Activity,Other accessory protein(s),All properties
1983 P Bedinger, B M Alberts The 3'-5' proofreading exonuclease of...
1983 S W Matson, Charles C Richardson DNA-dependent nucleoside 5'-triphosph...
1983 M J Engler, Charles C Richardson Bacteriophage T7 DNA replication. Syn...
1983 R L Lechner, Charles C Richardson A preformed, topologically stable rep...
1983 M J Engler, R L Lechner, Charles C Richardson Two forms of the DNA polymerase of ba... Cloned or native,Tagged,Full length or truncated,Specific Activity,Extension from RNA primer,Nick Extension,5-3' exo,Nucleotide Substitution Rate,Molecular Weight,Other accessory protein(s),All properties
1983 R L Lechner, M J Engler, Charles C Richardson Characterization of strand displaceme... Cloned or native,Tagged,Full length or truncated,Specific Activity,Nick Extension,3-5' exo,Other accessory protein(s),All properties
1983 S W Matson, Stanley Tabor, Charles C Richardson The gene 4 protein of bacteriophage T...
1982 H Randahl, I Slabý, A Holmgren An improved purification method and a...
1982 H Randahl Inhibition of the T7 DNA polymerase b...
1981 Stanley Tabor, Charles C Richardson Template recognition sequence for RNA...
1981 A Holmgren, G B Kallis, B Nordström A mutant thioredoxin from Escherichia...
1981 Louis J Romano, F Tamanoi, Charles C Richardson Initiation of DNA replication at the ...
1981 B Nordström, H Randahl, I Slaby, A Holmgren Characterization of bacteriophage T7 ... Cloned or native,Tagged,Full length or truncated,Specific Activity,3-5' exo,Molecular Weight,3-5' Exo Specific Activity,Other accessory protein(s),All properties
1979 K Hori, D F Mark, Charles C Richardson Deoxyribonucleic acid polymerase of b...
1979 S Adler, P Modrich T7-induced DNA polymerase. Characteri... Cloned or native,Tagged,Full length or truncated,Specific Activity,3-5' exo,3-5' Exo Specific Activity,Other accessory protein(s),All properties
1979 K Hori, D F Mark, Charles C Richardson Deoxyribonucleic acid polymerase of b... Cloned or native,Tagged,Full length or truncated,Specific Activity,Isoelectric Point,3-5' exo,KM,3-5' Exo Specific Activity,Other accessory protein(s),All properties
1979 Louis J Romano, Charles C Richardson Requirements for synthesis of ribonuc...
1978 R Kolodner, Charles C Richardson Gene 4 protein of bacteriophage T7. C...
1978 R Kolodner, Y Masamune, J E LeClerc, Charles C Richardson Gene 4 protein of bacteriophage T7. P...
1977 R Kolodner, Charles C Richardson Replication of duplex DNA by bacterio...
1976 D F Mark, Charles C Richardson Escherichia coli thioredoxin: a subun...
1975 P Modrich, Charles C Richardson Bacteriophage T7 deoxyribonucleic aci... Cloned or native,Tagged,Full length or truncated,Specific Activity,Molecular Weight,All properties
1975 P Modrich, Charles C Richardson Bacteriophage T7 Deoxyribonucleic aci... Cloned or native,Tagged,Full length or truncated,Specific Activity,Other accessory protein(s),All properties
1975 David C Hinkle, Charles C Richardson Bacteriophage T7 deoxyribonucleic aci...
1971 Y Masamune, Charles C Richardson Strand displacement during deoxyribon...
1971 P Grippo, Charles C Richardson Deoxyribonucleic acid polymerase of b... Cloned or native,Tagged,Full length or truncated,3-5' exo,All properties
1971 Paul T Englund The initial step of in vitro synthesi...
Protein sequence:

Using Polbase tables:

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