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Results for property: Template lesions

Detailed Results for Property

Use this page to examine all the the polymerases and references referring to the property: Template lesions.

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Polymerase Kingdom Family Reference Result Context
T7 Virus/Phage A Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Idles Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA
Vent A488L Archaeon B Comparative kinetics of nucleotide analog incorporation by vent DNA polymerase. Bypasses
Eco Pol I Eubacterium A Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins. Bypasses Reaction: Nucleotide incorporation; DNA lesion: Apurinic/Apyrimidinic (AP) site
Klenow fragment Eubacterium A Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: effect of proximal and distal template damage on DNA synthesis. Bypasses Reaction: Nucleotide incorporation; DNA lesion: 8-oxo-dG
Dpo4 Archaeon Y Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta. Bypasses Reaction: Nucleotide incorporation; Substrate: dATP; DNA lesion: Apurinic/Apyrimidinic (AP) site
Dpo4 Archaeon Y Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase. Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: 8-oxo-dG
Dpo4 Archaeon Y Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta. Bypasses Reaction: Nucleotide incorporation; Substrate: dATP; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol eta Eukaryote Y Emerging links between hypermutation of antibody genes and DNA polymerases. Bypasses Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: UV-induced Pyrimidine Dimer
Human Pol eta Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol eta Eukaryote Y Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Bypasses Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA
Human Pol eta Eukaryote Y Ubiquitylation of proliferating cell nuclear antigen and recruitment of human DNA polymerase eta. Bypasses Reaction: Nucleotide incorporation; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol eta Eukaryote Y Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. Bypasses Reaction: Nucleotide incorporation; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol eta Eukaryote Y Emerging links between hypermutation of antibody genes and DNA polymerases. Bypasses Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: 8-hydroxyguanine
Human Pol kappa Eukaryote Y Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene. Bypasses Reaction: Nucleotide incorporation
Human Pol kappa Eukaryote Y Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Bypasses Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA
Human Pol beta Eukaryote X DNA polymerase family X: function, structure, and cellular roles. Bypasses Reaction: Nucleotide incorporation
Human Pol beta Eukaryote X DNA polymerase family X: function, structure, and cellular roles. Bypasses Reaction: Nucleotide incorporation; Substrate: dCTP; DNA lesion: 8-oxo-dG
Human Pol beta Eukaryote X Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Stalls Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: OPdA
Human Pol beta Eukaryote X DNA polymerase family X: function, structure, and cellular roles. Bypasses Reaction: Nucleotide incorporation
Pfu Archaeon B Interaction of the family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases. Stalls Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: dUTP (uracil)
Pfu Archaeon B Interaction of the family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases. Stalls Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: dITP (inosine)
Human Pol lamba Eukaryote X DNA polymerase family X: function, structure, and cellular roles. Bypasses Reaction: Nucleotide incorporation; DNA lesion: 8-oxo-dG
Human Pol mu Eukaryote X DNA polymerase family X: function, structure, and cellular roles. Bypasses Reaction: Nucleotide incorporation; DNA lesion: Apurinic/Apyrimidinic (AP) site
Human Pol mu Eukaryote X DNA polymerase family X: function, structure, and cellular roles. Bypasses Reaction: Nucleotide incorporation; DNA lesion: 8-oxo-dG
Human Pol iota Eukaryote Y Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Idles Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA
Human Pol delta Eukaryote B Human replicative DNA polymerase δ can bypass T-T (6-4) ultraviolet photoproducts on template strands. Bypasses Reaction: Nucleotide incorporation; DNA lesion: TC 6,4 Photodimer
Human Pol theta Eukaryote A The human DINB1 gene encodes the DNA polymerase Poltheta. Stalls Reaction: Nucleotide incorporation; DNA lesion: TC 6,4 Photodimer
Human Pol theta Eukaryote A The human DINB1 gene encodes the DNA polymerase Poltheta. Stalls Reaction: Nucleotide incorporation; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol theta Eukaryote A The human DINB1 gene encodes the DNA polymerase Poltheta. Stalls Reaction: Nucleotide incorporation; DNA lesion: Apurinic/Apyrimidinic (AP) site
Pol eta Y52E Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pol eta Y52D Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pol eta Y52H Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pol eta Y52F Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pol eta Y52A Eukaryote Y Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
SsoDpo1 Archaeon B Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Bypasses Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA
Human Pol nu Eukaryote A Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Stalls Reaction: Nucleotide incorporation; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol nu Eukaryote A Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Stalls Reaction: Nucleotide incorporation; DNA lesion: Apurinic/Apyrimidinic (AP) site
Klenow Fragment D424A Eubacterium A Coordination between the polymerase and 5'-nuclease components of DNA polymerase I of Escherichia coli. Unspecified Reaction: Nucleotide incorporation
Tcr pol eta ? ? Cloning and characterization of DNA polymerase eta from Trypanosoma cruzi: roles for translesion bypass of oxidative damage. Stalls Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: 8-oxo-dG
Pfu V93Q Archaeon B Interaction of the family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases. Bypasses Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: dITP (inosine)
Pfu V93Q Archaeon B Interaction of the family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases. Bypasses Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: dUTP (uracil)
Ath pol eta Eukaryote Y Arabidopsis thaliana Y-family DNA polymerase eta catalyses translesion synthesis and interacts functionally with PCNA2. Bypasses Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pab pol D Archaeon B Intrinsic properties of the two replicative DNA polymerases of Pyrococcus abyssi in replicating abasic sites: possible role in DNA damage tolerance? Stalls Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: Apurinic/Apyrimidinic (AP) site
Pab pol B Archaeon B Intrinsic properties of the two replicative DNA polymerases of Pyrococcus abyssi in replicating abasic sites: possible role in DNA damage tolerance? Bypasses Reaction: Nucleotide incorporation; Substrate: dATP; DNA lesion: Apurinic/Apyrimidinic (AP) site

Version:20240415

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.