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Results for property: RT

Detailed Results for Property

Use this page to examine all the the polymerases and references referring to the property: RT.

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Polymerase Kingdom Family Reference Result Context
Klenow fragment Eubacterium A Fidelity of the reverse transcriptase of human immunodeficiency virus type 2. No
Klenow fragment Eubacterium A DNA polymerases from hyperthermophiles. Yes
Human Pol gamma Eukaryote A Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity. Yes
Human Pol gamma Eukaryote A Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity. Yes
Taq pol I Eubacterium A DNA polymerases from hyperthermophiles. Yes
HIV RT Virus/Phage RT Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis. Yes
HIV RT Virus/Phage RT Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations. Yes
HIV RT Virus/Phage RT Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Yes
HIV RT Virus/Phage RT HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Yes
HIV RT Virus/Phage RT Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Yes
HIV RT Virus/Phage RT Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. Yes
HIV RT Virus/Phage RT Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT Nucleoside and nucleotide analogue reverse transcriptase inhibitors: a clinical review of antiretroviral resistance. Yes
HIV RT Virus/Phage RT Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Yes
HIV RT Virus/Phage RT Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5 -chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses. Yes
HIV RT Virus/Phage RT Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. Yes
HIV RT Virus/Phage RT Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases. Yes
HIV RT Virus/Phage RT 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma. Yes
HIV RT Virus/Phage RT Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action. Yes
HIV RT Virus/Phage RT Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation. Yes
HIV RT Virus/Phage RT Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains. Yes
HIV RT Virus/Phage RT TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Yes
HIV RT Virus/Phage RT Nucleoside-analog resistance mutations in HIV-1 reverse transcriptase and their influence on polymerase fidelity and viral mutation rates. Yes
HIV RT Virus/Phage RT Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase. Yes
HIV RT Virus/Phage RT Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA. Yes
HIV RT Virus/Phage RT Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2. Yes
HIV RT Virus/Phage RT Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Yes
HIV RT Virus/Phage RT N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase. Yes
HIV RT Virus/Phage RT Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors. Yes
HIV RT Virus/Phage RT Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates. Yes
HIV RT Virus/Phage RT Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants. Yes
HIV RT Virus/Phage RT High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Yes
HIV RT Virus/Phage RT Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors. Yes
HIV RT Virus/Phage RT Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs). Yes
HIV RT Virus/Phage RT Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT Perspectives on the molecular mechanism of inhibition and toxicity of nucleoside analogs that target HIV-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT Exploring the effects of active site constraints on HIV-1 reverse transcriptase DNA polymerase fidelity. Yes
HIV RT Virus/Phage RT N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT Study on steady-state kinetics of nucleotide analogues incorporation by non-gel CE. Yes
HIV RT Virus/Phage RT Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action. Yes
HIV RT Virus/Phage RT Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities. Yes
HIV RT Virus/Phage RT Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities. Yes
HIV RT Virus/Phage RT HP 0.35, a cephalosporin degradation product is a specific inhibitor of lentiviral RNAses H. Yes
HIV RT Virus/Phage RT Lersivirine: a Non-Nucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus-1. Yes
HIV RT Virus/Phage RT Purification and partial characterization of equine infectious anemia virus reverse transcriptase. Yes
HIV RT Virus/Phage RT Fidelity of the reverse transcriptase of human immunodeficiency virus type 2. Yes
HIV RT Virus/Phage RT Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design. No
HIV RT Virus/Phage RT Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex. Yes
HIV RT Virus/Phage RT N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. Yes
HIV RT Virus/Phage RT Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. Yes
HIV RT Virus/Phage RT 3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase. Yes
HIV RT Virus/Phage RT The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation. Yes
HIV RT Virus/Phage RT HIV-1 reverse transcriptase inhibitors. Yes
MMuLV RT Virus/Phage RT The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus. Yes
MMuLV RT Virus/Phage RT Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro. Yes
MMuLV RT Virus/Phage RT Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates. Yes
Bst LF Eubacterium A DNA polymerases from hyperthermophiles. Yes
AMV Virus/Phage RT Purification and partial characterization of equine infectious anemia virus reverse transcriptase. Yes
AMV Virus/Phage RT Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates. Yes
AMV Virus/Phage RT Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro. Yes
AMV Virus/Phage RT RNA-dependent DNA polymerase activity of RNA tumor virus. VI. Processive mode of action of avian myeloblastosis virus polymerase. Yes
pB6B15.23 Unknown ? Purification and characterization of murine retroviral reverse transcriptase expressed in Escherichia coli. Yes
HIV RT K65R Virus/Phage RT Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. Yes
HIV RT K65R Virus/Phage RT The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. Yes
HIV RT K103NY181C Virus/Phage RT Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. Yes
HIV RT E138K Virus/Phage RT Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138. Yes
HIV RT K101E Virus/Phage RT Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138. Yes
HIV RT Y181C Virus/Phage RT High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Yes
HIV RT K103N Virus/Phage RT Lersivirine: a Non-Nucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus-1. Yes
HIV RT K103N Virus/Phage RT High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Yes
HIV RT K103N Virus/Phage RT N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Yes
HIV RT K103N Virus/Phage RT Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design. Yes
HIV RT K103N Virus/Phage RT Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. Yes
HIV RT L100I Virus/Phage RT Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors. Yes
HIV RT L100I Virus/Phage RT High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Yes
MMuLV RT N term R116A Virus/Phage RT Structural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase. Yes
HIV2 RT Virus/Phage RT Fidelity of the reverse transcriptase of human immunodeficiency virus type 2. Yes
HIV RT M184V Virus/Phage RT Exploring the effects of active site constraints on HIV-1 reverse transcriptase DNA polymerase fidelity. Yes
Bsu Pol X Eubacterium X Characterization of a Bacillus subtilis 64-kDa DNA polymerase X potentially involved in DNA repair. No
hTERT Eukaryote RT The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity. Yes
hTERT Eukaryote RT Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Yes
hTERT L866Y Eukaryote RT The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity. Yes
hTERT V867A Eukaryote RT The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity. Yes
hTERT V867T Eukaryote RT The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity. Yes
hTERT V867M Eukaryote RT The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity. Yes
HIV RT F61A Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. Yes
HIV RT F61W Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. Yes
HIV RT F61L Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. Yes
HIV RT F61Y Virus/Phage RT Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. Yes
FeLV RT Virus/Phage RT Comparison of DNA polymerase activities between recombinant feline immunodeficiency and leukemia virus reverse transcriptases. Yes
FIV RT Virus/Phage RT Comparison of DNA polymerase activities between recombinant feline immunodeficiency and leukemia virus reverse transcriptases. Yes
EIAV RT Virus/Phage RT Purification and partial characterization of equine infectious anemia virus reverse transcriptase. Yes
Sce pol gamma Eukaryote A Construction and validation of a yeast model system for studying in vivo the susceptibility to nucleoside analogues of DNA polymerase gamma allelic variants. Yes
IN ? ? Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 Is critical for HIV-1 infection. Yes

Version:20240424

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.