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Results for property: Frameshift Error Rate

Detailed Results for Property

Use this page to examine all the the polymerases and references referring to the property: Frameshift Error Rate.

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Polymerase Kingdom Family Reference Result Context
T7 Virus/Phage A Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity. 0.0015 errors/bp Technique: Forward mutational (1mM dNTP)
T7 Virus/Phage A Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit. 4.5E-07 errors/bp Technique: M13mp2 forward mutation assay (-1 reading frame)
T7 Virus/Phage A Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit. 3.7E-07 errors/bp Technique: M13mp2 forward mutation assay (+1 reading frame)
Vent Archaeon B Optimization of the polymerase chain reaction with regard to fidelity: modified T7, Taq, and vent DNA polymerases. 4.5E-05 errors/bp
Vent Archaeon B Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity. 0.0034 errors/bp Technique: Forward mutational (1mM dNTP)
T4 Virus/Phage B Effect of accessory proteins on T4 DNA polymerase replication fidelity. 1.2E-06 errors/bp Technique: M13mp2 forward mutation assay
T4 Virus/Phage B Spectrum of spontaneous frameshift mutations. Sequences of bacteriophage T4 rII gene frameshifts. 3E-07 errors/bp
RB69 D222AD327A Virus/Phage B Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. 520 Mutation frequency (relative to WT) Technique: RB69 rII 131 reversion
T4 A737V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 0.48 Mutation frequency (relative to WT) Technique: T4 rII UV6 reversion
T4 A737V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 0.13 Mutation frequency (relative to WT) Technique: T4 rII 131 reversion
T4 A737V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 11 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC47; 1b-b7, a - frameshift))
T4 A737V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 4.2 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC41; 1b-b2, a - frameshift))
T4 A737V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 1.5 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC40; 1b-b4, a - frameshift))
T4 A737V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 22 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rX146; b6-mb, a + frameshift))
T4 A737V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 3.5 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC7; b3-mb, a + frameshift))
T4 A737V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 6 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC11; b1-mb, a + frameshift))
T4 A737V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 0.65 Mutation frequency (relative to WT) Technique: T4 rII 114 reversion
T4 A777V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 1.4 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC11; b1-mb, a + frameshift))
T4 A777V Virus/Phage B General antimutators are improbable. 1.1 Mutation frequency (relative to WT) Technique: Forward mutational
T4 A777V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 125 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rX146; b6-mc, a + frameshift))
T4 A777V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 0.63 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC41; 1b-b2, a - frameshift)
T4 A777V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 3.4 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC47; 1b-b7, a - frameshift))
T4 A777V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 0.2 Mutation frequency (relative to WT) Technique: T4 rII 131 reversion
T4 A777V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 0.18 Mutation frequency (relative to WT) Technique: T4 rII UV6 reversion
T4 A777V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 0.51 Mutation frequency (relative to WT) Technique: T4 rII 114 reversion
T4 A777V Virus/Phage B Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. 2.3 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC7; b3-mb, a + frameshift))
Klenow fragment Eubacterium A A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity. 0.0102 errors/bp Technique: Reversion
Klenow fragment Eubacterium A Analyzing fidelity of DNA polymerases. 8E-05 errors/bp Technique: Reversion
Klenow fragment Eubacterium A The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. 6E-07 errors/bp Technique: M13mp2 forward mutation assay (1 uM dNTP, error rate is upper limit (≤))
Dpo4 Archaeon Y Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site. 0.0023 errors/bp Technique: M13mp2 forward mutation assay
Human Pol eta Eukaryote Y The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. 0.0024 errors/bp Technique: M13mp2 forward mutation assay
Dbh Archaeon Y The mutational specificity of the Dbh lesion bypass polymerase and its implications. 0.03 errors/bp
Human Pol gamma Eukaryote A The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. 1.2E-06 errors/bp Technique: M13mp2 forward mutation assay
Eco Pol IV Eubacterium Y Fidelity of Escherichia coli DNA polymerase IV. Preferential generation of small deletion mutations by dNTP-stabilized misalignment. 0.00021 errors/bp Technique: M13mp2 forward mutation assay
Eco Pol V Eubacterium Y Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis. 2.3E-05 errors/bp
Human Pol kappa Eukaryote Y The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. 0.0018 errors/bp Technique: M13mp2 forward mutation assay
Rat Pol beta Eukaryote X The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations. 0.0355 errors/bp Technique: M13mp2 forward mutation assay
Taq pol I Eubacterium A Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. 2.44E-05 errors/bp
Taq pol I Eubacterium A High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. 4.76E-06 errors/bp Technique: Reversion (High fidelity conditions)
Taq pol I Eubacterium A High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. 5.26E-05 errors/bp Technique: Reversion (Low fidelity conditions)
HIV RT Virus/Phage RT Mutation Rates and Intrinsic Fidelity of Retroviral Reverse Transcriptases 0.00023 errors/bp
HIV RT Virus/Phage RT In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT. 8E-06 errors/bp
HIV RT Virus/Phage RT Analyzing fidelity of DNA polymerases. 0.0047 errors/bp Technique: Reversion
Eco Pol III Eubacterium C Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis. 1.4E-06 errors/bp
Eco Pol III Eubacterium C The base substitution and frameshift fidelity of Escherichia coli DNA polymerase III holoenzyme in vitro. 5E-09 errors/bp
Human Pol lamba Eukaryote X The frameshift infidelity of human DNA polymerase lambda. Implications for function. 0.0049 errors/bp Technique: M13mp2 forward mutation assay
Klenow (exo-) Eubacterium A Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase. 1.4E-05 errors/bp
Klenow (exo-) Eubacterium A Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase. 0.00054 errors/bp
Vent (exo-) Archaeon B Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity. 0.0094 errors/bp Technique: Forward mutational (1mM dNTP)
Replinase Unknown ? Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity. 0.0064 errors/bp Technique: Forward mutational (1mM dNTP)
AMV Virus/Phage RT Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro. 1.15E-05 errors/bp Technique: M13mp2 opal codon reversion assay
AMV Virus/Phage RT Mutation Rates and Intrinsic Fidelity of Retroviral Reverse Transcriptases 1E-05 errors/bp
RB69 Y567A Virus/Phage B Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. 4.5 Mutation frequency (relative to WT) Technique: RB69 rII 131 reversion
RB69 L561A Virus/Phage B The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination. 1.2 errors/bp Technique: RB69 rII 131 reversion
RB69 L561A Virus/Phage B The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination. 4.5 errors/bp Technique: RB69 rII UV232 reversion
Human Pol alpha Eukaryote B Fidelity and error specificity of the alpha catalytic subunit of Escherichia coli DNA polymerase III. 4E-05 errors/bp Technique: Forward mutational
Human Pol alpha Eukaryote B Fidelity and error specificity of the alpha catalytic subunit of Escherichia coli DNA polymerase III. 0.00031 errors/bp Technique: Reversion
KF D424A Eubacterium A The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. 5E-06 errors/bp Technique: M13mp2 forward mutation assay (1mM dNTP; combined with D355A,E357A results)
KF D424A Eubacterium A The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. 0.0043 errors/bp Technique: Forward mutational (1 uM dNTP)
KF D355AE357A Eubacterium A The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. 5E-06 errors/bp Technique: M13mp2 forward mutation assay (1mM dNTP; combined with D424A results)
KF(515-928) Eubacterium A The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. 1.3E-05 errors/bp Technique: M13mp2 forward mutation assay (1mM dNTP)
Sce Pol eta Eukaryote Y The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. 0.00093 errors/bp Technique: M13mp2 forward mutation assay
Sce Pol delta Eukaryote B The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. 1.3E-05 errors/bp Technique: M13mp2 forward mutation assay
RB69 Y567S Virus/Phage B Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. 14 Mutation frequency (relative to WT) Technique: RB69 rII 131 reversion
RB69 Y567T Virus/Phage B Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. 32 Mutation frequency (relative to WT) Technique: RB69 rII 131 reversion
PFV RT Virus/Phage RT In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT. 2.1E-05 errors/bp
Chicken Pol beta Eukaryote X The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations. 0.012 errors/bp Technique: M13mp2 forward mutation assay
MutD5 Pol III Eubacterium C The base substitution and frameshift fidelity of Escherichia coli DNA polymerase III holoenzyme in vitro. 100 Mutation frequency (relative to WT)
MutD5 Pol III Eubacterium C The base substitution and frameshift fidelity of Escherichia coli DNA polymerase III holoenzyme in vitro. 5E-07 errors/bp
Sce Pol I Eukaryote B Fidelity of DNA polymerase I and the DNA polymerase I-DNA primase complex from Saccharomyces cerevisiae. 5.88E-05 errors/bp Technique: M13mp2 forward mutation assay

Version:20240415

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.