T4

From bacteriophage T4 (aliases:phage T4, bacteriophage polymerase T4)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for T4.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

T4 is a family B enzyme from bacteriophage T4.

The phage T4 DNA polymerase was the first DNA polymerase demonstrated to be essential for DNA replication in vivo.  The purified DNA polymerase, like all DNA polymerases, replicates DNA in the 5' to 3' direction; the T4 DNA polymerase also has a 3' to 5' exonuclease proofreading activity that increases the fidelity of DNA replication.  The T4 DNA polymerase replication complex was one of the first to be reconstituted in vitro.  Structures of the T4-related RB69 DNA polymerase are useful models for family B DNA polymerases.

 

Selected Properties for T4:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (9) No (4) 3.0e-07-1.2e-06 errors/bp (2) 1.0e-08-2.0e-04 errors/bp (8) 2.0e-08 errors/bp (1)
Year Authors Title Results by property
2013 Babho Devadoss, Irene Lee, Anthony J Berdis Devadoss B2013
2011 Brian A Kelch, Debora L Makino, Mike E O'Donnell, John Kuriyan Kelch BA2011
2011 Chen Song, Chen Zhang, Meiping Zhao Song C2011
2010 Vasiliy M Petrov, Swarnamala Ratnayaka, Jim D Karam Petrov VM2010
2010 Linda J Reha-Krantz Reha-Krantz LJ2010
2009 Sri Ranjini Arumugam, Tae-Hee Lee, Stephen J Benkovic Arumugam SR2009
2009 Maria Manosas, Michelle M Spiering, Zhihao Zhuang, Stephen J Benkovic, Vincent Croquette Manosas M2009
2009 Anna Trzemecka, Danuta Płochocka, Anna Bebenek Trzemecka A2009 Kd,All properties
2009 Linda J Reha-Krantz Reha-Krantz LJ2009
2009 Akira Tachibana, Kazuo Tohiguchi, Takayuki Ueno, Yuichi Setogawa, Ayako Harada, Toshizumi Tanabe Tachibana A2009
2008 J Gury, L Zinger, L Gielly, P Taberlet, RA Geremia Gury J2008
2008 Scott W Nelson, Ravindra Kumar, Stephen J Benkovic Nelson SW2008
2008 Linda J Reha-Krantz Reha-Krantz LJ2008
2008 Usharani Subuddhi, Matthew Hogg, Linda J Reha-Krantz Subuddhi U2008
2008 Gary E Schultz, John W Drake Schultz GE2008
2007 Dina Tleugabulova, Linda J Reha-Krantz Tleugabulova D2007
2007 Diana Vineyard, Xuemei Zhang, Alison Donnelly, Irene Lee, Anthony J Berdis Vineyard D2007
2007 Anthony J Berdis, David McCutcheon Berdis AJ2007
2007 Scott W Nelson, Stephen J Benkovic Nelson SW2007
2007 Nancy G Nossal, Alexander M Makhov, Paul D Chastain, Charles E Jones, Jack D Griffith Nossal NG2007 Extension from RNA primer,3-5' exo,5-3' exo,All properties
2007 Elizabeth Fidalgo da Silva, Linda J Reha-Krantz Fidalgo da Silva E2007 kcat,All properties
2007 Giuseppina Blanca, Emmanuelle Delagoutte, Nicolas Tanguy Le Gac, Neil P Johnson, Giuseppe Baldacci, Giuseppe Villani Blanca G2007
2006 R Derike Smiley, Zhihao Zhuang, Stephen J Benkovic, Gordon G Hammes Smiley RD2006
2006 Xuemei Zhang, Alison Donnelly, Irene Lee, Anthony J Berdis Zhang X2006
2006 Chithra Hariharan, Linda B Bloom, Sandra A Helquist, Eric T Kool, Linda J Reha-Krantz Hariharan C2006
2006 Gary E Schultz, Geraldine T Carver, John W Drake Schultz GE2006
2006 Irene Lee, Anthony J Berdis Lee I2006
2006 John W Drake Drake JW2006
2006 Matthew Hogg, Wendy Cooper, Linda J Reha-Krantz, Susan S Wallace Hogg M2006
2005 Jon P Anderson, Bernhard Angerer, Lawrence A Loeb Anderson JP2005 Cloned or native,Tagged,Full length or truncated,3-5' exo,5-3' exo,Application name,Incorporation of non-standard nucleotides,All properties
2005 Jun Xi, Zhiquan Zhang, Zhihao Zhuang, Jingsong Yang, Michelle M Spiering, Gordon G Hammes, Stephen J Benkovic Xi J2005
2005 Chithra Hariharan, Linda J Reha-Krantz Hariharan C2005 Methods Featured,All properties
2004 Jingsong Yang, Zhihao Zhuang, Rosa Maria Roccasecca, Michael A Trakselis, Stephen J Benkovic Yang J2004 Full length or truncated,Kd,Vmax,All properties
2004 Vasiliy M Petrov, Jim D Karam Petrov VM2004
2004 Charles E Jones, Timothy C Mueser, Nancy G Nossal Jones CE2004
2004 Wen Xin, Da-Wei Huang, Yi-Ming Zhang, Liang Geng Xin W2004
2004 Nicolas Tanguy Le Gac, Emmanuelle Delagoutte, Matthieu Germain, Giuseppe Villani Tanguy Le Gac N2004
2004 C X Wang, E Zakharova, Jinming Li, Catherine M Joyce, Jianhong Wang, William H Konigsberg Wang CX2004 kcat,All properties
2003 Laura Tsujikawa, Michael Weinfield, Linda J Reha-Krantz Tsujikawa L2003
2003 Faoud T Ishmael, Michael A Trakselis, Stephen J Benkovic Ishmael FT2003
2003 Emmanuelle Delagoutte, Peter H von Hippel Delagoutte E2003
2003 S Ikeda, H Imai, M Yamada Ikeda S2003
2003 Jingsong Yang, Michael A Trakselis, Rosa Maria Roccasecca, Stephen J Benkovic Yang J2003
2003 Edmunds Z Reineks, Anthony J Berdis Reineks EZ2003
2002 Vasiliy M Petrov, San-San Ng, Jim D Karam Petrov VM2002
2002 Vasiliy M Petrov, Jim D Karam Petrov VM2002
2002 Farid A Kadyrov, John W Drake Kadyrov FA2002
2002 David Jeruzalmi, Mike E O'Donnell, John Kuriyan Jeruzalmi D2002
2002 Giuseppe Villani, Nicolas Tanguy Le Gac, Luc Wasungu, Dominique Y Burnouf, Robert P P Fuchs, Paul E Boehmer Villani G2002
2002 Vineeta Khare, Kristin A Eckert Khare V2002 Extension from RNA primer,3-5' exo,5-3' exo,All properties
2002 Elizabeth Fidalgo da Silva, Subhrangsu S Mandal, Linda J Reha-Krantz Fidalgo da Silva E2002
2002 Megan J Davey, David Jeruzalmi, John Kuriyan, Mike E O'Donnell Davey MJ2002
2002 Subhrangsu S Mandal, Elizabeth Fidalgo da Silva, Linda J Reha-Krantz Mandal SS2002
2001 Isao Kuraoka, P Robins, Chikahide Masutani, Fumio Hanaoka, Didier Gasparutto, Jean Cadet, Richard D Wood, T Lindahl Kuraoka I2001
2001 Anthony J Berdis Berdis AJ2001
2001 Emmanuelle Delagoutte, Peter H von Hippel Delagoutte E2001
2001 Michael A Trakselis, M U Mayer, Faoud T Ishmael, Rosa Maria Roccasecca, Stephen J Benkovic Trakselis MA2001
2001 Farid A Kadyrov, John W Drake Kadyrov FA2001
2001 S C Alley, Michael A Trakselis, M U Mayer, Faoud T Ishmael, A D Jones, Stephen J Benkovic Alley SC2001
2001 Michael A Trakselis, S C Alley, E Abel-Santos, Stephen J Benkovic Trakselis MA2001
2001 T C Lin, C X Wang, Catherine M Joyce, William H Konigsberg Lin TC2001
2001 Nancy G Nossal, K C Dudas, K N Kreuzer Nossal NG2001
2001 M Bhagwat, Nancy G Nossal Bhagwat M2001 RNase H,All properties
2001 M I Hadjimarcou, Robert J Kokoska, Thomas D Petes, Linda J Reha-Krantz Hadjimarcou MI2001
2000 E F da Silva, Linda J Reha-Krantz da Silva EF2000
2000 I Moarefi, David Jeruzalmi, J Turner, Mike E O'Donnell, John Kuriyan Moarefi I2000
2000 S C Alley, E Abel-Santos, Stephen J Benkovic Alley SC2000
2000 Andrey R Pavlov, Jim D Karam Pavlov AR2000
2000 Paul D Chastain, Alexander M Makhov, Nancy G Nossal, Jack D Griffith Chastain PD2000
1999 E Elisseeva, Subhrangsu S Mandal, Linda J Reha-Krantz Elisseeva E1999 kcat,All properties
1999 Zafer Hatahet, Mian Zhou, Linda J Reha-Krantz, Hiroshi Ide, S W Morrical, Susan S Wallace Hatahet Z1999
1999 D Canceill, Enrique Viguera, S Dusko Ehrlich Canceill D1999
1999 S C Alley, A D Jones, P Soumillion, Stephen J Benkovic Alley SC1999
1998 J W Drake, B Charlesworth, D Charlesworth, J F Crow Drake JW1998
1998 Nancy G Nossal Nossal NG1998
1998 P Keohavong, R Shukla, A Melacrinos, B W Day, Linda J Reha-Krantz Keohavong P1998
1998 F J Wang, L S Ripley Wang FJ1998
1998 L S Yeh, Tien Hsu, Jim D Karam Yeh LS1998
1998 P Soumillion, D J Sexton, Stephen J Benkovic Soumillion P1998
1998 J M Beechem, M R Otto, Linda B Bloom, R Eritja, Linda J Reha-Krantz, Myron F Goodman Beechem JM1998 Methods Featured,All properties
1998 M R Otto, Linda B Bloom, Myron F Goodman, J M Beechem Otto MR1998 Methods Featured,All properties
1998 D J Sexton, B F Kaboord, Anthony J Berdis, T E Carver, Stephen J Benkovic Sexton DJ1998
1998 P Wu, N Nossal, Stephen J Benkovic Wu P1998
1998 R P Baker, Linda J Reha-Krantz Baker RP1998
1998 Linda J Reha-Krantz Reha-Krantz LJ1998
1998 Zafer Hatahet, Mian Zhou, Linda J Reha-Krantz, S W Morrical, Susan S Wallace Hatahet Z1998
1998 Linda J Reha-Krantz, L A Marquez, E Elisseeva, R P Baker, Linda B Bloom, H B Dunford, Myron F Goodman Reha-Krantz LJ1998
1998 L C Kroutil, M W Frey, B F Kaboord, Thomas A Kunkel, Stephen J Benkovic Kroutil LC1998 3-5' exo,5-3' exo,Frameshift Error Rate,Nucleotide Substitution Rate,All properties
1998 L A Smith, John W Drake Smith LA1998
1998 Myron F Goodman, K D Fygenson Goodman MF1998
1997 P Pietroni, M C Young, G J Latham, Peter H von Hippel Pietroni P1997
1997 C C Wang, A Pavlov, Jim D Karam Wang CC1997
1997 G J Latham, D J Bacheller, P Pietroni, Peter H von Hippel Latham GJ1997
1997 Holly Kloos Dressman, C C Wang, Jim D Karam, John W Drake Dressman HK1997
1997 D J Sexton, Anthony J Berdis, Stephen J Benkovic Sexton DJ1997
1997 T E Carver, D J Sexton, Stephen J Benkovic Carver TE1997 Cloned or native,Full length or truncated,Processivity,All properties
1997 Anthony J Berdis, Stephen J Benkovic Berdis AJ1997
1997 Myron F Goodman Goodman MF1997
1997 D Kong, Nancy G Nossal, Charles C Richardson Kong D1997
1997 L D Goodrich, T C Lin, E K Spicer, C Jones, William H Konigsberg Goodrich LD1997
1997 G J Latham, D J Bacheller, P Pietroni, Peter H von Hippel Latham GJ1997
1996 Linda J Reha-Krantz, C Wong Reha-Krantz LJ1996
1996 L A Marquez, Linda J Reha-Krantz Marquez LA1996
1996 R D Schrock, B Alberts Schrock RD1996 Full length or truncated,Processivity,Vmax,All properties
1996 A K Abdus Sattar, T C Lin, C Jones, William H Konigsberg Abdus Sattar AK1996 KM,kcat,All properties
1996 Jianhong Wang, Pengbo Yu, T C Lin, William H Konigsberg, Thomas A Steitz Wang J1996
1996 Linda J Reha-Krantz, R L Nonay, R S Day, Samuel H Wilson Reha-Krantz LJ1996
1996 John W Drake Drake JW1996
1996 D J Sexton, T E Carver, Anthony J Berdis, Stephen J Benkovic Sexton DJ1996
1996 Anthony J Berdis, P Soumillion, Stephen J Benkovic Berdis AJ1996
1996 F Dong, S E Weitzel, Peter H von Hippel Dong F1996
1996 M W Frey, S T Frey, W D Horrocks, B F Kaboord, Stephen J Benkovic Frey MW1996
1995 M K Reddy, S E Weitzel, S S Daube, Thale C Jarvis, Peter H von Hippel Reddy MK1995
1995 B Liu, B M Alberts Liu B1995
1995 M W Frey, L C Sowers, David P Millar, Stephen J Benkovic Frey MW1995
1995 S Creighton, Myron F Goodman Creighton S1995 Nucleotide Substitution Rate,All properties
1995 Linda J Reha-Krantz Reha-Krantz LJ1995
1995 C C Wang, L S Yeh, Jim D Karam Wang CC1995
1995 S A Stocki, R L Nonay, Linda J Reha-Krantz Stocki SA1995
1995 V L Kaiser, L S Ripley Kaiser VL1995
1995 Nancy G Nossal, D M Hinton, L J Hobbs, P Spacciapoli Nossal NG1995
1995 Parvathi Chary, R Stephen Lloyd Chary P1995
1995 B F Kaboord, Stephen J Benkovic Kaboord BF1995
1995 Linda J Reha-Krantz Reha-Krantz LJ1995
1994 P Spacciapoli, Nancy G Nossal Spacciapoli P1994 Cloned or native,Full length or truncated,Specific Activity,3-5' exo,All properties
1994 Linda J Reha-Krantz, R L Nonay Reha-Krantz LJ1994
1994 P Hentosh, P Grippo Hentosh P1994
1994 P Spacciapoli, Nancy G Nossal Spacciapoli P1994
1994 Linda B Bloom, M R Otto, R Eritja, Linda J Reha-Krantz, Myron F Goodman, J M Beechem Bloom LB1994
1994 M E Santos, J W Drake Santos ME1994
1994 Unknown1994
1994 N N Khan, Linda J Reha-Krantz, George E Wright Khan NN1994
1994 T C Lin, G Karam, William H Konigsberg Lin TC1994 3-5' exo,KM,kcat,All properties
1994 V Gopalakrishnan, Stephen J Benkovic Gopalakrishnan V1994
1994 Andrey R Pavlov, Jim D Karam Pavlov AR1994
1994 Unknown1994
1994 K J Hacker, B M Alberts Hacker KJ1994
1994 K J Hacker, B M Alberts Hacker KJ1994 Cloned or native,Full length or truncated,Processivity,3-5' exo,5-3' exo,All properties
1993 John W Drake Drake JW1993
1993 M M Waye Waye MM1993
1993 M W Frey, Nancy G Nossal, T L Capson, Stephen J Benkovic Frey MW1993
1993 Linda J Reha-Krantz, R L Nonay, S Stocki Reha-Krantz LJ1993
1993 B Liu, M L Wong, R L Tinker, E P Geiduschek, B M Alberts Liu B1993
1993 B F Kaboord, Stephen J Benkovic Kaboord BF1993
1993 H Kong, R B Kucera, William E Jack Kong H1993 Processivity,KM,All properties
1993 Linda J Reha-Krantz, R L Nonay Reha-Krantz LJ1993
1993 M K Reddy, S E Weitzel, Peter H von Hippel Reddy MK1993
1992 Unknown1992
1992 J L Kuijper, K M Wiren, L D Mathies, C L Gray, F S Hagen Kuijper JL1992
1992 M K Reddy, S E Weitzel, Peter H von Hippel Reddy MK1992
1992 Linda J Reha-Krantz Reha-Krantz LJ1992
1992 T L Capson, J A Peliska, B F Kaboord, M W Frey, C Lively, M Dahlberg, Stephen J Benkovic Capson TL1992
1992 M C Young, M K Reddy, Peter H von Hippel Young MC1992
1992 Nancy G Nossal Nossal NG1992
1991 M M Munn, B M Alberts Munn MM1991
1991 M M Munn, B M Alberts Munn MM1991
1991 N N Khan, George E Wright, Neal C Brown Khan NN1991
1991 M D Andrake, Jim D Karam Andrake MD1991
1991 John W Drake Drake JW1991 Overall Error Rate,All properties
1991 Linda J Reha-Krantz, S Stocki, R L Nonay, E Dimayuga, L D Goodrich, William H Konigsberg, E K Spicer Reha-Krantz LJ1991
1991 W Y Yap, K N Kreuzer Yap WY1991
1991 T L Capson, Stephen J Benkovic, Nancy G Nossal Capson TL1991
1991 Thale C Jarvis, J W Newport, Peter H von Hippel Jarvis TC1991
1991 S W Morrical, M L Wong, B M Alberts Morrical SW1991
1990 S S Wang, V A Zakian Wang SS1990
1990 Linda J Reha-Krantz Reha-Krantz LJ1990
1990 C Tuerk, S Eddy, D Parma, L Gold Tuerk C1990
1990 A W Stoker Stoker AW1990
1990 C Tuerk, L Gold Tuerk C1990
1990 S W Morrical, B M Alberts Morrical SW1990
1990 T A Cha, B M Alberts Cha TA1990
1990 C Bonne-Andrea, M L Wong, B M Alberts Bonne-Andrea C1990
1990 Tien Hsu, Jim D Karam Hsu T1990
1990 Unknown1990
1990 Thale C Jarvis, D M Ring, S S Daube, Peter H von Hippel Jarvis TC1990
1989 J Rush, T C Lin, M Quinones, E K Spicer, I Douglas, K R Williams, William H Konigsberg Rush J1989
1989 J Rush, William H Konigsberg Rush J1989
1989 Linda J Reha-Krantz Reha-Krantz LJ1989
1989 P Bedinger, M Munn, B M Alberts Bedinger P1989
1989 P Keohavong, William G Thilly Keohavong P1989 Nucleotide Substitution Rate,All properties
1989 Katarzyna Bebenek, Thomas A Kunkel Bebenek K1989
1989 T A Cha, B M Alberts Cha TA1989
1989 Thale C Jarvis, L S Paul, J W Hockensmith, Peter H von Hippel Jarvis TC1989
1989 R W Richardson, Nancy G Nossal Richardson RW1989
1988 Linda J Reha-Krantz Reha-Krantz LJ1988
1988 Unknown1988
1988 P Keohavong, A G Kat, N F Cariello, William G Thilly Keohavong P1988
1988 John W Drake Drake JW1988
1988 Hiroshi Ide, Susan S Wallace Ide H1988
1988 Thomas A Kunkel Kunkel TA1988
1988 E K Spicer, J Rush, C Fung, Linda J Reha-Krantz, Jim D Karam, William H Konigsberg Spicer EK1988
1987 Unknown1987
1987 N K Sinha Sinha NK1987
1987 Nancy G Nossal, D M Hinton Nossal NG1987 Extension from RNA primer,All properties
1987 T C Lin, J Rush, E K Spicer, William H Konigsberg Lin TC1987
1987 Linda J Reha-Krantz Reha-Krantz LJ1987
1986 M C Hu, N Davidson Hu MC1986
1986 Linda J Reha-Krantz, E M Liesner, S Parmaksizoglu, S Stocki Reha-Krantz LJ1986
1986 J M Clark, G P Beardsley Clark JM1986
1986 T A Cha, B M Alberts Cha TA1986 Extension from RNA primer,All properties
1986 T Formosa, B M Alberts Formosa T1986
1986 L S Ripley, A Clark Ripley LS1986
1986 L S Ripley, A Clark, J G deBoer Ripley LS1986 Frameshift Error Rate,All properties
1986 M F Charette, D T Weaver, M L DePamphilis Charette MF1986
1986 Unknown1986
1985 Linda J Reha-Krantz, J K Lambert Reha-Krantz LJ1985
1985 Masamitsu Yamaguchi, E A Hendrickson, M L DePamphilis Yamaguchi M1985
1985 R L Hopkins, Myron F Goodman Hopkins RL1985
1985 D M Hinton, Lynn L Silver, Nancy G Nossal Hinton DM1985
1985 K N Kreuzer, B M Alberts Kreuzer KN1985
1985 R M Dale, B A McClure, J P Houchins Dale RM1985
1985 John Petruska, Myron F Goodman Petruska J1985
1985 P W Doetsch, G L Chan, W A Haseltine Doetsch PW1985
1984 A P Gupta, P A Benkovic, Stephen J Benkovic Gupta AP1984
1984 C V Jongeneel, T Formosa, B M Alberts Jongeneel CV1984
1984 D C Mace, B M Alberts Mace DC1984 Processivity,Nucleotide incorporation accessory protein(s),All properties
1984 T C Rowe, K M Tewey, L F Liu Rowe TC1984
1984 Thomas A Kunkel, Lawrence A Loeb, Myron F Goodman Kunkel TA1984 Processivity,Nucleotide Substitution Rate,All properties
1984 D N Mhaskar, Myron F Goodman Mhaskar DN1984
1984 D C Mace, B M Alberts Mace DC1984
1984 D C Mace Mace DC1984
1984 Linda J Reha-Krantz, E M Liesner Reha-Krantz LJ1984
1984 Linda J Reha-Krantz, S Parmaksizoglu Reha-Krantz LJ1984
1984 M D Topal Topal MD1984
1984 R S Lasken, Myron F Goodman Lasken RS1984
1983 Myron F Goodman, S Keener, S Guidotti, E W Branscomb Goodman MF1983
1983 P Gauss, D H Doherty, L Gold Gauss P1983
1983 P Bedinger, M Hochstrasser, C V Jongeneel, B M Alberts Bedinger P1983
1983 T Formosa, R L Burke, B M Alberts Formosa T1983
1983 K C Deen, T A Landers, M Berninger Deen KC1983
1983 Unknown1983
1983 P Bedinger, B M Alberts Bedinger P1983 Exonuclease accessory protein(s),All properties
1983 L S Ripley, B W Glickman, N B Shoemaker Ripley LS1983
1983 L S Ripley, N B Shoemaker Ripley LS1983
1982 Bernard Strauss, S Rabkin, D Sagher, P Moore Strauss B1982
1982 M Venkatesan, Nancy G Nossal Venkatesan M1982
1982 A Gupta, C DeBrosse, Stephen J Benkovic Gupta A1982
1982 P J Romaniuk, F Eckstein Romaniuk PJ1982
1982 A C Roth, Nancy G Nossal, Paul T Englund Roth AC1982
1981 Linda J Reha-Krantz, M J Bessman Reha-Krantz LJ1981
1981 C C Huang, J E Hearst, B M Alberts Huang CC1981
1981 R C Miller, E T Young, R H Epstein, H M Krisch, T Mattson, A Bolle Miller RC1981
1981 Chin-Chi Liu, B M Alberts Liu CC1981
1980 M D Topal, S R DiGuiseppi, N K Sinha Topal MD1980 KM,All properties
1980 N K Sinha, C F Morris, B M Alberts Sinha NK1980 Vmax,Nucleotide incorporation accessory protein(s),All properties
1980 Chin-Chi Liu, B M Alberts Liu CC1980 Extension from RNA primer,All properties
1980 U Hibner, B M Alberts Hibner U1980
1980 M D Challberg, Paul T Englund Challberg MD1980
1980 Nancy G Nossal Nossal NG1980 Extension from RNA primer,All properties
1980 M A Conkling, R E Koch, John W Drake Conkling MA1980
1980 C Schroeder, J Jantschak Schroeder C1980
1980 C C Huang, J E Hearst Huang CC1980
1979 Chin-Chi Liu, R L Burke, U Hibner, J Barry, B Alberts Liu CC1979
1979 C F Morris, L A Moran, B M Alberts Morris CF1979
1979 Lynn L Silver, Nancy G Nossal Silver LL1979
1979 C F Morris, H Hama-Inaba, D Mace, N K Sinha, B Alberts Morris CF1979
1979 W M Huang Huang WM1979
1979 G Mosig, A Luder, G Garcia, R Dannenberg, S Bock Mosig G1979
1979 Nancy G Nossal Nossal NG1979
1979 Nancy G Nossal, B M Peterlin Nossal NG1979
1979 L K Clayton, Myron F Goodman, E W Branscomb, D J Galas Clayton LK1979 KM,All properties
1978 J R Piperno, B M Alberts Piperno JR1978
1978 J R Piperno, R G Kallen, B M Alberta Piperno JR1978
1978 A Ronen, C Halevy, N Kass Ronen A1978
1977 J Chao, M Leach, J Karam Chao J1977
1977 Myron F Goodman, R Hopkins, W C Gore Goodman MF1977
1977 B Alberts, R Sternglanz Alberts B1977
1977 Linda J Reha-Krantz, M J Bessman Reha-Krantz LJ1977
1977 Myron F Goodman, G M Lee Goodman MF1977
1977 W E Williams, J W Drake Williams WE1977
1976 R E Koch, M K McGaw, John W Drake Koch RE1976
1976 K Y Lo, M J Bessman Lo KY1976
1976 F D Gillin, Nancy G Nossal Gillin FD1976
1976 F D Gillin, Nancy G Nossal Gillin FD1976
1976 K Y Lo, M J Bessman Lo KY1976 KM,Vmax,All properties
1976 P M Bingham, R H Baltz, L S Ripley, John W Drake Bingham PM1976
1975 R C Miller Miller RC1975
1975 F D Gillin, Nancy G Nossal Gillin FD1975 KM,Vmax,All properties
1975 C F Morris, N K Sinha, B M Alberts Morris CF1975
1975 L S Ripley Ripley LS1975
1974 Myron F Goodman, M J Bessman, N R Bachur Goodman MF1974
1974 I. Robert Lehman Lehman IR1974
1974 Nancy G Nossal Nossal NG1974 Nick Extension,All properties
1974 J D Karam, M G Bowles Karam JD1974
1974 C F Schnitzlein, I Albrecht, John W Drake Schnitzlein CF1974
1974 M J Bessman, N Muzyczka, Myron F Goodman, R L Schnaar Bessman MJ1974
1973 M S Hershfield Hershfield MS1973 Cloned or native,Tagged,Full length or truncated,3-5' exo,All properties
1973 R L Schnaar, N Muzyczka, M J Bessman Schnaar RL1973
1973 M S Hershfield, Nancy G Nossal Hershfield MS1973
1973 Jim D Karam, P V O'Donnell Karam JD1973
1973 A Panet, J H van de Sande, P C Loewen, H G Khorana, A J Raae, J R Lillehaug, K Kleppe Panet A1973
1972 U Ray, L Bartenstein, J W Drake Ray U1972
1972 D Brutlag, Arthur Kornberg Brutlag D1972 Vmax,All properties
1972 P V O'Donnell, Jim D Karam O'Donnell PV1972
1972 N Muzyczka, R L Poland, M J Bessman Muzyczka N1972
1972 N Prashad, J Hosoda Prashad N1972
1972 F A de Vries, C J Swart-Idenburg, A de Waard de Vries FA1972
1972 W M Huang, I. Robert Lehman Huang WM1972 Cloned or native,Tagged,Full length or truncated,Specific Activity,3-5' exo,Molecular Weight,All properties
1972 M S Hershfield, Nancy G Nossal Hershfield MS1972
1972 M N Swartz, Hiroaki Nakamura, I. Robert Lehman Swartz MN1972
1971 Paul T Englund Englund PT1971
1971 Nancy G Nossal, M S Hershfield Nossal NG1971 KM,Vmax,All properties
1971 R E Koch Koch RE1971
1971 H Bernstein Bernstein H1971
1971 J W Drake Drake JW1971
1970 R E Koch, John W Drake Koch RE1970
1970 B M Alberts, L Frey Alberts BM1970
1970 R B Kelly, N R Cozzarelli, M P Deutscher, I. Robert Lehman, Arthur Kornberg Kelly RB1970 5-3' exo,All properties
1970 B M Alberts Alberts BM1970
1970 John W Drake, E O Greening Drake JW1970
1968 Mehran Goulian, Z J Lucas, Arthur Kornberg Goulian M1968 Full length or truncated,Specific Activity,Strand Displacement,Gap fill,3-5' exo,5-3' exo,Molecular Weight,Percent/Fold Effect,Optimal pH,All properties
1968 M W Baldy Baldy MW1968
1968 J F Speyer, D Rosenberg Speyer JF1968
1967 H Bernstein Bernstein H1967
1967 John W Drake, J McGuire Drake JW1967
1967 N R Cozzarelli, N E Melechen, T M Jovin, Arthur Kornberg Cozzarelli NR1967
1966 H R Warner, J E Barnes Warner HR1966
1966 J F Speyer, Jim D Karam, A B Lenny Speyer JF1966
1965 A De Waard, A V Paul, I. Robert Lehman De Waard A1965
1963 Unknown1963
Protein sequence:
DNA sequence:
Name 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
T4 E26K
T4 R29S
T4 D49Y
T4 I50 uplication/A580S
T4 I50iiA580S
T4 I50T
T4 I50LP424L 2.0e-01 Mutation frequency (relative to WT) (1)
T4 I50TP424L 1.0e-01 Mutation frequency (relative to WT) (1)
T4 I50L 1.0e+02-1.0e+02 Mutation frequency (relative to WT) (2)
T4 W69op
T4 G82D 4.5e+01-3.0e+02 Mutation frequency (relative to WT) (5)
T4 N84K 1.0e+02 Mutation frequency (relative to WT) (1)
T4 A89T 8.0e+00 Mutation frequency (relative to WT) (1)
T4 A89TD363N 3.8e+00-1.9e+03 Mutation frequency (relative to WT) (14)
T4 A89TD363N/Q731S 2.4e+00 Mutation frequency (relative to WT) (1)
T4 A89TD363N/Q731Y 1.5e+01 Mutation frequency (relative to WT) (1)
T4 E98K
T4 D112AE114A/L412M
T4 D112AE114A No (1) 3.0e+02-3.0e+02 Mutation frequency (relative to WT) (2)
T4 D112N
T4 D112AD324A
T4 D112AD219A
T4 D112A
T4 E114A
T4 P123L
T4 D131G 1.3e+02-2.7e+03 Mutation frequency (relative to WT) (3)
T4 D131N 1.5e+01-4.5e+01 Mutation frequency (relative to WT) (2)
T4 G172S
T4 D189AE191A 1.1e+01-3.0e+01 Mutation frequency (relative to WT) (3)
T4 D189A 1.0e+00-4.0e+00 Mutation frequency (relative to WT) (3)
T4 E191AD324G 5.1e+02-1.8e+03 errors/bp, Mutation frequency (relative to WT) (3)
T4 E191A 2.0e+00-6.0e+00 Mutation frequency (relative to WT) (3)
T4 W202am
T4 W202Q 1.0e+00 Mutation frequency (relative to WT) (1)
T4 W202AMB
T4 W202Y 1.0e+00 Mutation frequency (relative to WT) (1)
T4 W202SQ386S
T4 W202S 2.0e-01-1.9e+00 Mutation frequency (relative to WT) (2)
T4 W213Q
T4 W213S No (1) 1.0e+00 Mutation frequency (relative to WT) (1)
T4 W213Y 1.5e-01 Mutation frequency (relative to WT) (1)
T4 W213am
T4 N214A
T4 F218A
T4 D219AD324A 3.1e+02 Mutation frequency (relative to WT) (1)
T4 D219N
T4 D219A No (2) 4.0e-05-7.6e+02 errors/bp, Mutation frequency (relative to WT) (4) 1.2e-05 errors/bp (1)
T4 R225H
T4 R226H
T4 K229A
T4 Y254K 7.7e+01 Mutation frequency (relative to WT) (1)
T4 Y254L 7.0e+00 Mutation frequency (relative to WT) (1)
T4 Y254Q 4.7e+01 Mutation frequency (relative to WT) (1)
T4 Y254G 7.2e+01 Mutation frequency (relative to WT) (1)
T4 Y254S 3.6e+01 Mutation frequency (relative to WT) (1)
T4 G255SA737V 4.0e-02 Mutation frequency (relative to WT) (1)
T4 G255A 1.1e+02 Mutation frequency (relative to WT) (1)
T4 G255S 4.8e+01-3.3e+02 Mutation frequency (relative to WT) (5)
T4 S256L 1.5e+01 Mutation frequency (relative to WT) (1)
T4 S256G 3.4e+01 Mutation frequency (relative to WT) (1)
T4 S256K 1.1e+01 Mutation frequency (relative to WT) (1)
T4 S256Q 1.0e+00 Mutation frequency (relative to WT) (1)
T4 S256Y 1.0e+00 Mutation frequency (relative to WT) (1)
T4 K257S 1.0e+00 Mutation frequency (relative to WT) (1)
T4 K257G 6.0e+00 Mutation frequency (relative to WT) (1)
T4 K257L 3.0e+00 Mutation frequency (relative to WT) (1)
T4 K257Q 4.0e+00 Mutation frequency (relative to WT) (1)
T4 K257Y 3.0e+00 Mutation frequency (relative to WT) (1)
T4 E288K
T4 G298D 1.7e+02 Mutation frequency (relative to WT) (1)
T4 K299AY320F
T4 G304D 1.5e+02 Mutation frequency (relative to WT) (1)
T4 L309P 7.2e+02 Mutation frequency (relative to WT) (1)
T4 Y317C 4.1e+02-2.1e+03 Mutation frequency (relative to WT) (4)
T4 Y320FD324A
T4 Y320F
T4 Y320A
T4 D324G 5.6e+01-2.8e+02 Mutation frequency (relative to WT) (3)
T4 D324N
T4 D324A 6.0e+01 Mutation frequency (relative to WT) (1)
T4 V325AL340P/Q731am 1.7e+01-4.5e+03 Mutation frequency (relative to WT) (8)
T4 V325AL340P 2.0e+01-4.2e+03 Mutation frequency (relative to WT) (17)
T4 V325A 1.1e+02 Mutation frequency (relative to WT) (1)
T4 D863up/R335C 1.0e-01 Mutation frequency (relative to WT) (1)
T4 R335C 1.0e-02-1.0e-02 Mutation frequency (relative to WT) (2)
T4 R335CP381L
T4 R335CP424L 3.0e-02 Mutation frequency (relative to WT) (1)
T4 R335CP378L 1.3e-01 Mutation frequency (relative to WT) (1)
T4 L340P 5.5e+01-2.0e+03 Mutation frequency (relative to WT) (16)
T4 L340PQ731am 4.0e+00-2.9e+03 Mutation frequency (relative to WT) (8)
T4 S345F 2.0e-02 Mutation frequency (relative to WT) (1)
T4 S345P 2.5e+01 Mutation frequency (relative to WT) (1)
T4 D863up/S345F 5.0e-02 Mutation frequency (relative to WT) (1)
T4 V355A 5.0e+00 Mutation frequency (relative to WT) (1)
T4 D363N 5.0e+00 Mutation frequency (relative to WT) (1)
T4 S369A
T4 P378L 5.0e+00 Mutation frequency (relative to WT) (1)
T4 P378H
T4 Q380K 5.0e+00 Mutation frequency (relative to WT) (1)
T4 P381L
T4 Q386AMBW844AMB
T4 Q386S 1.0e+00 errors/bp (1)
T4 Q386AMB
T4 Q386K 1.0e+00 Mutation frequency (relative to WT) (1)
T4 Q386am
T4 Q386Y 2.0e-01-1.2e+00 Mutation frequency (relative to WT) (2)
T4 E395K 1.4e+01 Mutation frequency (relative to WT) (1)
T4 D809N
T4 D408A
T4 S411TL412M 6.0e-02 Mutation frequency (relative to WT) (1)
T4 S411T
T4 L412MA737V 2.0e-02 Mutation frequency (relative to WT) (1)
T4 L412I 9.0e-02 Mutation frequency (relative to WT) (1)
T4 L412M 7.7e+00-9.2e+00 Mutation frequency (relative to WT) (5)
T4 L412MI417V 2.5e-02 Mutation frequency (relative to WT) (1)
T4 L412MP424L 1.0e-01 Mutation frequency (relative to WT) (1)
T4 I417V 4.0e-03-1.0e-01 Mutation frequency (relative to WT) (2)
T4 P424L 2.0e-02 Mutation frequency (relative to WT) (1)
T4 P424I 1.0e-01 Mutation frequency (relative to WT) (1)
T4 Q430K 1.0e+00 Mutation frequency (relative to WT) (1)
T4 Q430S 1.0e+00 Mutation frequency (relative to WT) (1)
T4 Q430Y 1.0e+00 Mutation frequency (relative to WT) (1)
T4 Q430am
T4 P447L 1.3e+00 Mutation frequency (relative to WT) (1)
T4 N456TE881K 3.2e+02 Mutation frequency (relative to WT) (1)
T4 W458am
T4 W458K 2.0e-01 Mutation frequency (relative to WT) (1)
T4 W458Q 1.0e-01 Mutation frequency (relative to WT) (1)
T4 W458S 5.0e-02-1.4e+00 Mutation frequency (relative to WT) (2)
T4 W458Y 2.0e-01 Mutation frequency (relative to WT) (1)
T4 Y460F
T4 Y460H
T4 G466S
T4 Q478H
T4 Q478R
T4 Q478RA488V 1.0e+02-2.7e+02 Mutation frequency (relative to WT) (4)
T4 W482am
T4 W482K 1.0e+00 Mutation frequency (relative to WT) (1)
T4 W482S 1.0e+00 Mutation frequency (relative to WT) (1)
T4 W482Q 6.0e+00 Mutation frequency (relative to WT) (1)
T4 W482Y 1.0e+00 Mutation frequency (relative to WT) (1)
T4 F487L
T4 K557A
T4 L567F
T4 R573C
T4 R578op 1.0e+00 Mutation frequency (relative to WT) (1)
T4 N579L
T4 Q592K 1.0e-01 Mutation frequency (relative to WT) (1)
T4 Q592amW844am
T4 Q592S 1.0e-02-1.3e+00 Mutation frequency (relative to WT) (2)
T4 Q592am
T4 W593AMB
T4 W593am
T4 W593S 1.0e+00 Mutation frequency (relative to WT) (1)
T4 W593Y 7.0e+00 Mutation frequency (relative to WT) (1)
T4 W593K 1.0e+00 Mutation frequency (relative to WT) (1)
T4 W593Q 1.0e+00 Mutation frequency (relative to WT) (1)
T4 G652el/K653G
T4 C668S
T4 M671I
T4 C687S
T4 G694SQ731Y
T4 G694S 3.0e+00-2.7e+01 Mutation frequency (relative to WT) (5)
T4 G694SQ731S 1.2e-01 Mutation frequency (relative to WT) (1)
T4 K702SK705A
T4 M725I
T4 M725V
T4 Q730Y 1.0e-01 Mutation frequency (relative to WT) (1)
T4 Q730S 1.0e-03-1.4e+00 Mutation frequency (relative to WT) (2)
T4 Q730AMB
T4 Q730am
T4 Q730K 1.0e-01 Mutation frequency (relative to WT) (1)
T4 Q731K 1.0e-02 Mutation frequency (relative to WT) (1)
T4 Q731Y 1.0e-02-1.5e-02 Mutation frequency (relative to WT) (2)
T4 Q731am 1.0e-01-2.2e+00 Mutation frequency (relative to WT) (6)
T4 Q731S 1.0e-03-1.3e+00 Mutation frequency (relative to WT) (3)
T4 A737V Yes (1) 1.3e-01-2.2e+01 Mutation frequency (relative to WT) (9) 2.0e-03-9.0e-01 Mutation frequency (relative to WT) (5) 1.0e+00 Mutation frequency (relative to WT) (1)
T4 A737VL771F
T4 E743K 1.1e+01 Mutation frequency (relative to WT) (1)
T4 S756P 1.3e+01 Mutation frequency (relative to WT) (1)
T4 L771H 8.0e+00 Mutation frequency (relative to WT) (1)
T4 L771F Yes (1) 3.0e-01 Mutation frequency (relative to WT) (1)
T4 A777V 1.8e-01-1.3e+02 Mutation frequency (relative to WT) (9)
T4 C798S
T4 M827I
T4 C841S
T4 A843V
T4 W844S 2.0e-03 Mutation frequency (relative to WT) (1)
T4 W844Y 1.0e-01 Mutation frequency (relative to WT) (1)
T4 W844am
T4 D863 uplication 1.0e+01 Mutation frequency (relative to WT) (1)
T4 D863 uplication 1.0e+01 Mutation frequency (relative to WT) (1)
T4 D863 uplication 1.0e+01 Mutation frequency (relative to WT) (1)
T4 F868S
T4 C880S
T4 CB121
T4 tsA58
T4 257[KEIYS]uplication
T4 L141
T4 [L771+D] 2.9e+01 Mutation frequency (relative to WT) (1)
T4 [L771+V] 2.2e+01 Mutation frequency (relative to WT) (1)
T4 L56
T4 N881
T4 N895
T4 L98
T4 271[L]uplication 7.4e+01 Mutation frequency (relative to WT) (1)
T4 64[KD]uplication 5.0e+01 Mutation frequency (relative to WT) (1)
T4 N892
T4 K653Δ
T4 N887
T4 N388
T4 N698
All Polymerases | 140 Results
Entry contributed by: Linda J Reha-Krantz

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