| T7 |
Virus/Phage |
A
|
T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Deoxyribonucleic acid polymerase of bacteriophage T7. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Thermostable DNA polymerases. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Single-molecule studies of the effect of template tension on T7 DNA polymerase activity. |
Yes |
|
| T7 |
Virus/Phage |
A
|
The thioredoxin binding domain of bacteriophage T7 DNA polymerase confers processivity on Escherichia coli DNA polymerase I. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Processive proofreading and the spatial relationship between polymerase and exonuclease active sites of bacteriophage phi29 DNA polymerase. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Deoxyribonucleic acid polymerase of bacteriophage T7. Purification and properties of the phage-encoded subunit, the gene 5 protein. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Characterization of bacteriophage T7 DNA polymerase purified to homogeneity by antithioredoxin immunoadsorbent chromatography. |
Yes |
|
| T7 |
Virus/Phage |
A
|
T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups. |
Yes |
|
| T7 |
Virus/Phage |
A
|
Characterization of strand displacement synthesis catalyzed by bacteriophage T7 DNA polymerase. |
Yes |
|
| 9egN |
Archaeon |
B
|
Cloning of thermostable DNA polymerases from hyperthermophilic marine Archaea with emphasis on Thermococcus sp. 9 degrees N-7 and mutations affecting 3'-5' exonuclease activity. |
Yes |
|
| 9egN |
Archaeon |
B
|
DNA polymerases from hyperthermophiles. |
Yes |
|
| TGO |
Archaeon |
B
|
Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius. |
Yes |
|
| TGO |
Archaeon |
B
|
The 3'-5' proofreading exonuclease of archaeal family-B DNA polymerase hinders the copying of template strand deaminated bases. |
Yes |
|
| KOD1 |
Archaeon |
B
|
Catalyzing "hot" reactions: enzymes from hyperthermophilic Archaea. |
Yes |
|
| KOD1 |
Archaeon |
B
|
Characterization of DNA polymerase from Pyrococcus sp. strain KOD1 and its application to PCR. |
Yes |
|
| RB69 |
Virus/Phage |
B
|
Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family. |
Yes |
|
| Vent |
Archaeon |
B
|
Fidelity of Thermococcus litoralis DNA polymerase (Vent) in PCR determined by denaturing gradient gel electrophoresis. |
Yes |
|
| Vent |
Archaeon |
B
|
Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity. |
Yes |
|
| Vent |
Archaeon |
B
|
Incorporation of reporter-labeled nucleotides by DNA polymerases. |
Yes |
|
| Vent |
Archaeon |
B
|
In vitro replication slippage by DNA polymerases from thermophilic organisms. |
Yes |
|
| Vent |
Archaeon |
B
|
DNA polymerases from hyperthermophiles. |
Yes |
|
| Vent |
Archaeon |
B
|
Characterization of a DNA polymerase from the hyperthermophile archaea Thermococcus litoralis. Vent DNA polymerase, steady state kinetics, thermal stability, processivity, strand displacement, and exonuclease activities. |
Yes |
|
| T4 D219A |
Virus/Phage |
B
|
Probing DNA polymerase-DNA interactions: examining the template strand in exonuclease complexes using 2-aminopurine fluorescence and acrylamide quenching. |
No |
|
| T4 D219A |
Virus/Phage |
B
|
Effect of accessory proteins on T4 DNA polymerase replication fidelity. |
No |
|
| T4 |
Virus/Phage |
B
|
Enzymatic synthesis of deoxyribonucleic acid. XXV. Purification and properties of deoxyribonucleic acid polymerase induced by infection with phage T4. |
Yes |
|
| T4 |
Virus/Phage |
B
|
Effect of accessory proteins on T4 DNA polymerase replication fidelity. |
Yes |
|
| T4 |
Virus/Phage |
B
|
A single mutation in bacteriophage T4 DNA polymerase (A737V, tsL141) decreases its processivity as a polymerase and increases its processivity as a 3'-->5' exonuclease. |
Yes |
|
| T4 |
Virus/Phage |
B
|
Incorporation of reporter-labeled nucleotides by DNA polymerases. |
Yes |
|
| T4 |
Virus/Phage |
B
|
The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis. |
Yes |
|
| T4 |
Virus/Phage |
B
|
The slow dissociation of the T4 DNA polymerase holoenzyme when stalled by nucleotide omission. An indication of a highly processive enzyme. |
Unspecified |
|
| T4 |
Virus/Phage |
B
|
On the role of deoxyribonucleic acid polymerase in determining mutation rates. Characterization of the defect in the T4 deoxyribonucleic acid polymerase caused by the ts L88 mutation. |
Yes |
|
| T4 |
Virus/Phage |
B
|
Isolation, characterization, and kinetic properties of truncated forms of T4 DNA polymerase that exhibit 3'-5' exonuclease activity. |
Yes |
|
| T4 |
Virus/Phage |
B
|
On the exonuclease activity of phage T4 deoxyribonucleic acid polymerase. |
Yes |
|
| T4 |
Virus/Phage |
B
|
Architecture of the bacteriophage T4 replication complex revealed with nanoscale biopointers. |
Yes |
|
| RB69 D222AD327A |
Virus/Phage |
B
|
Use of 2-aminopurine fluorescence to study the role of the beta hairpin in the proofreading pathway catalyzed by the phage T4 and RB69 DNA polymerases. |
No |
|
| RB69 beta hairpin- |
Virus/Phage |
B
|
Use of 2-aminopurine fluorescence to study the role of the beta hairpin in the proofreading pathway catalyzed by the phage T4 and RB69 DNA polymerases. |
No |
|
| RB69 D222AD327A beta hairpin- |
Virus/Phage |
B
|
Use of 2-aminopurine fluorescence to study the role of the beta hairpin in the proofreading pathway catalyzed by the phage T4 and RB69 DNA polymerases. |
No |
|
| T4 W213S |
Virus/Phage |
B
|
DNA polymerase proofreading: active site switching catalyzed by the bacteriophage T4 DNA polymerase. |
No |
|
| T4 A737V |
Virus/Phage |
B
|
A single mutation in bacteriophage T4 DNA polymerase (A737V, tsL141) decreases its processivity as a polymerase and increases its processivity as a 3'-->5' exonuclease. |
Yes |
|
| T4 L771F |
Virus/Phage |
B
|
A single mutation in bacteriophage T4 DNA polymerase (A737V, tsL141) decreases its processivity as a polymerase and increases its processivity as a 3'-->5' exonuclease. |
Yes |
|
| RB69 G258S |
Virus/Phage |
B
|
Use of 2-aminopurine fluorescence to study the role of the beta hairpin in the proofreading pathway catalyzed by the phage T4 and RB69 DNA polymerases. |
No |
|
| RB69 G258SD222A/D237A |
Virus/Phage |
B
|
Use of 2-aminopurine fluorescence to study the role of the beta hairpin in the proofreading pathway catalyzed by the phage T4 and RB69 DNA polymerases. |
No |
|
| T4 D112AE114A |
Virus/Phage |
B
|
DNA polymerase proofreading: active site switching catalyzed by the bacteriophage T4 DNA polymerase. |
No |
|
| Eco Pol I |
Eubacterium |
A
|
Characterization of DNA polymerase I*, a form of DNA polymerase I found in Escherichia coli expressing SOS functions. |
Yes |
|
| Eco Pol I |
Eubacterium |
A
|
The steady state kinetic parameters and non-processivity of Escherichia coli deoxyribonucleic acid polymerase I. |
Yes |
|
| Eco Pol I |
Eubacterium |
A
|
Deoxyribonucleic acid polymerase: two distinct enzymes in one polypeptide. I. A proteolytic fragment containing the polymerase and 3' leads to 5' exonuclease functions. |
Yes |
|
| Eco Pol I |
Eubacterium |
A
|
Deoxyribonucleic acid polymerase: two distinct enzymes in one polypeptide. II. A proteolytic fragment containing the 5' leads to 3' exonuclease function. Restoration of intact enzyme functions from the two proteolytic fragments. |
Yes |
|
| Eco Pol I |
Eubacterium |
A
|
Enzymatic synthesis of deoxyribonucleic acid. XXXV. A 3'-hydroxylribonucleotide binding site of Escherichia coli deoxyribonucleic acid polymerase. |
Yes |
|
| Eco Pol I |
Eubacterium |
A
|
Enzymatic synthesis of deoxyribonucleic acid. XXXII. Replication of duplex deoxyribonucleic acid by polymerase at a single strand break. |
Yes |
|
| Eco Pol I |
Eubacterium |
A
|
Enzymatic synthesis of deoxyribonucleic acid. XXVII. Chemical modifications of deoxyribonucleic acid polymerase. |
Unspecified |
|
| Eco Pol I |
Eubacterium |
A
|
ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XIV. FURTHER PURIFICATION AND PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI. |
Unspecified |
|
| Eco Pol I |
Eubacterium |
A
|
Thermostable DNA polymerases. |
Yes |
|
| Eco Pol I |
Eubacterium |
A
|
Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins. |
Yes |
|
| Eco Pol I |
Eubacterium |
A
|
Incorporation of reporter-labeled nucleotides by DNA polymerases. |
No |
|
| Klenow fragment |
Eubacterium |
A
|
Deoxyribonucleic acid polymerase: two distinct enzymes in one polypeptide. I. A proteolytic fragment containing the polymerase and 3' leads to 5' exonuclease functions. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
Synthesis of novel poly(dG)-poly(dG)-poly(dC) triplex structure by Klenow exo- fragment of DNA polymerase I. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
In vitro synthesis of uniform poly(dG)-poly(dC) by Klenow exo- fragment of polymerase I. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
Identification of a new motif required for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): the RRRY motif is necessary for the binding of single-stranded DNA substrate and the template strand of the mismatched duplex. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
Fidelity of the reverse transcriptase of human immunodeficiency virus type 2. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
Miscoding potential of the N2-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free Klenow fragment of Escherichia coli DNA polymerase I. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
DNA polymerases from hyperthermophiles. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
Contribution of polar residues of the J-helix in the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): Q677 regulates the removal of terminal mismatch. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
Deoxyribonucleic acid polymerase: two distinct enzymes in one polypeptide. II. A proteolytic fragment containing the 5' leads to 3' exonuclease function. Restoration of intact enzyme functions from the two proteolytic fragments. |
Yes |
|
| Klenow fragment |
Eubacterium |
A
|
The 3'-5' exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction. |
Yes |
|
| Dpo4 |
Archaeon |
Y
|
Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site. |
No |
|
| Human Pol eta |
Eukaryote |
Y
|
Low fidelity DNA synthesis by human DNA polymerase-eta. |
No |
|
| Human Pol eta |
Eukaryote |
Y
|
Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. |
Yes |
|
| Human Pol eta |
Eukaryote |
Y
|
Error rate and specificity of human and murine DNA polymerase eta. |
No |
|
| Human Pol eta |
Eukaryote |
Y
|
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. |
No |
|
| Human Pol eta |
Eukaryote |
Y
|
Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
Thermostable DNA polymerases. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
Exonucleolytic proofreading by a mammalian DNA polymerase. |
Yes |
|
| Human Pol gamma |
Eukaryote |
A
|
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. |
Yes |
|
| Eco Pol IV |
Eubacterium |
Y
|
The beta clamp targets DNA polymerase IV to DNA and strongly increases its processivity. |
No |
|
| Eco Pol IV |
Eubacterium |
Y
|
The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis. |
No |
|
| Human Pol kappa |
Eukaryote |
Y
|
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. |
No |
|
| Human Pol kappa |
Eukaryote |
Y
|
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. |
No |
|
| Human Pol kappa |
Eukaryote |
Y
|
Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene. |
No |
|
| Human Pol beta |
Eukaryote |
X
|
DNA polymerase family X: function, structure, and cellular roles. |
No |
|
| Human Pol beta |
Eukaryote |
X
|
Thermostable DNA polymerases. |
No |
|
| Human Pol beta |
Eukaryote |
X
|
Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. |
No |
|
| Human Pol beta |
Eukaryote |
X
|
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. |
No |
|
| Rat Pol beta |
Eukaryote |
X
|
Autonomous 3'-->5' exonucleases can proofread for DNA polymerase beta from rat liver. |
Yes |
|
| T5 |
Virus/Phage |
A
|
Exonuclease associated with bacteriophage T5-Induced DNA polymerase. |
Yes |
|
| Streptococcus pneumoniae Pol I |
Eubacterium |
A
|
Streptococcus pneumoniae DNA polymerase I lacks 3'-to-5' exonuclease activity: localization of the 5'-to-3' exonucleolytic domain. |
No |
|
| Streptococcus pneumoniae Pol I |
Eubacterium |
A
|
The 5' to 3' exonuclease activity of DNA polymerase I is essential for Streptococcus pneumoniae. |
No |
|
| Streptococcus pneumoniae Pol I |
Eubacterium |
A
|
Characterization of the polA gene of Streptococcus pneumoniae and comparison of the DNA polymerase I it encodes to homologous enzymes from Escherichia coli and phage T7. |
Yes |
|
| Taq pol I |
Eubacterium |
A
|
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. |
No |
|
| Taq pol I |
Eubacterium |
A
|
Thermostable DNA polymerases. |
No |
|
| Taq pol I |
Eubacterium |
A
|
Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. |
No |
|
| Taq pol I |
Eubacterium |
A
|
Characterization of the 5' to 3' nuclease activity of Thermus aquaticus DNA polymerase on fluorogenic double-stranded probes. |
No |
|
| Taq pol I |
Eubacterium |
A
|
Fidelity of Thermococcus litoralis DNA polymerase (Vent) in PCR determined by denaturing gradient gel electrophoresis. |
No |
|
| Taq pol I |
Eubacterium |
A
|
High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. |
No |
|
| Taq pol I |
Eubacterium |
A
|
DNA polymerases from hyperthermophiles. |
No |
|
| Taq pol I |
Eubacterium |
A
|
Incorporation of reporter-labeled nucleotides by DNA polymerases. |
No |
|
| Tth Pol I |
Eubacterium |
A
|
Reverse transcription and DNA amplification by a Thermus thermophilus DNA polymerase. |
No |
|
| Tma Pol III |
Eubacterium |
C
|
Thermostable DNA polymerases. |
Yes |
|
| Tne pol |
Eubacterium |
A
|
Domain exchange: chimeras of Thermus aquaticus DNA polymerase, Escherichia coli DNA polymerase I and Thermotoga neapolitana DNA polymerase. |
Yes |
|
| HIV RT |
Virus/Phage |
RT
|
Purification and partial characterization of equine infectious anemia virus reverse transcriptase. |
No |
|
| HIV RT |
Virus/Phage |
RT
|
Fidelity of the reverse transcriptase of human immunodeficiency virus type 2. |
No |
|
| HIV RT |
Virus/Phage |
RT
|
Human immunodeficiency virus 1 reverse transcriptase. Template binding, processivity, strand displacement synthesis, and template switching. |
No |
|
| HIV RT |
Virus/Phage |
RT
|
Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH. |
No |
|
| Pfu |
Archaeon |
B
|
High-fidelity amplification using a thermostable DNA polymerase isolated from Pyrococcus furiosus. |
Yes |
|
| Pfu |
Archaeon |
B
|
DNA polymerases from hyperthermophiles. |
Yes |
|
| Pfu |
Archaeon |
B
|
The 3'-5' proofreading exonuclease of archaeal family-B DNA polymerase hinders the copying of template strand deaminated bases. |
Yes |
|
| Pfu |
Archaeon |
B
|
Incorporation of reporter-labeled nucleotides by DNA polymerases. |
Yes |
|
| Eco Pol III |
Eubacterium |
C
|
Fidelity of Escherichia coli DNA polymerase III holoenzyme. The effects of beta, gamma complex processivity proteins and epsilon proofreading exonuclease on nucleotide misincorporation efficiencies. |
Yes |
|
| Eco Pol III |
Eubacterium |
C
|
Thermostable DNA polymerases. |
Yes |
|
| Eco Pol III |
Eubacterium |
C
|
Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins. |
Yes |
|
| Eco Pol III |
Eubacterium |
C
|
The base substitution and frameshift fidelity of Escherichia coli DNA polymerase III holoenzyme in vitro. |
Yes |
|
| Tth Pol III |
Eubacterium |
C
|
DNA polymerase III holoenzyme from Thermus thermophilus identification, expression, purification of components, and use to reconstitute a processive replicase. |
Yes |
|
| Human Pol lamba |
Eukaryote |
X
|
DNA polymerase lambda, a novel DNA repair enzyme in human cells. |
No |
|
| Human Pol lamba |
Eukaryote |
X
|
The frameshift infidelity of human DNA polymerase lambda. Implications for function. |
No |
|
| Human Pol lamba |
Eukaryote |
X
|
DNA polymerase family X: function, structure, and cellular roles. |
No |
|
| Human Pol mu |
Eukaryote |
X
|
DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. |
No |
|
| Human Pol mu |
Eukaryote |
X
|
Highly frequent frameshift DNA synthesis by human DNA polymerase mu. |
No |
|
| Human Pol mu |
Eukaryote |
X
|
DNA polymerase family X: function, structure, and cellular roles. |
No |
|
| Human Pol iota |
Eukaryote |
Y
|
Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota. |
No |
|
| Human Pol iota |
Eukaryote |
Y
|
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. |
No |
|
| Phi29 |
Virus/Phage |
B
|
Involvement of the "linker" region between the exonuclease and polymerization domains of phi29 DNA polymerase in DNA and TP binding. |
Yes |
|
| Phi29 |
Virus/Phage |
B
|
Functional characterization of highly processive protein-primed DNA polymerases from phages Nf and GA-1, endowed with a potent strand displacement capacity. |
Yes |
|
| Phi29 |
Virus/Phage |
B
|
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. |
Yes |
|
| Phi29 |
Virus/Phage |
B
|
TempliPhi, phi29 DNA polymerase based rolling circle amplification of templates for DNA sequencing. |
Yes |
|
| Phi29 |
Virus/Phage |
B
|
Functional importance of bacteriophage phi29 DNA polymerase residue Tyr148 in primer-terminus stabilisation at the 3'-5' exonuclease active site. |
Yes |
|
| Phi29 |
Virus/Phage |
B
|
Phi29 DNA polymerase residues Tyr59, His61 and Phe69 of the highly conserved ExoII motif are essential for interaction with the terminal protein. |
Yes |
|
| Phi29 |
Virus/Phage |
B
|
Processive proofreading and the spatial relationship between polymerase and exonuclease active sites of bacteriophage phi29 DNA polymerase. |
Yes |
|
| Phi29 |
Virus/Phage |
B
|
The bacteriophage phi 29 DNA polymerase, a proofreading enzyme. |
Yes |
|
| PGBD Pol I |
Archaeon |
B
|
Fidelity and predominant mutations produced by deep vent wild-type and exonuclease-deficient DNA polymerases during in vitro DNA amplification. |
Yes |
|
| PGBD Pol I |
Archaeon |
B
|
Incorporation of reporter-labeled nucleotides by DNA polymerases. |
Yes |
|
| PGBD Pol I |
Archaeon |
B
|
DNA polymerases from hyperthermophiles. |
Yes |
|
| Bst |
Eubacterium |
A
|
Thermostable DNA polymerases. |
No |
|
| Bst |
Eubacterium |
A
|
Thermostable Bst DNA polymerase I lacks a 3'-->5' proofreading exonuclease activity. |
No |
|
| Bsu (large fragment) |
Eubacterium |
?
|
ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XV. PURIFICATION AND PROPERTIES OF A POLYMERASE FROM BACILLUS SUBTILIS. |
No |
|
| MMuLV RT |
Virus/Phage |
RT
|
Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro. |
No |
|
| Bst LF |
Eubacterium |
A
|
DNA polymerases from hyperthermophiles. |
No |
|
| Bst LF |
Eubacterium |
A
|
Thermostable Bst DNA polymerase I lacks a 3'-->5' proofreading exonuclease activity. |
No |
|
| Bst LF |
Eubacterium |
A
|
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. |
No |
|
| Bsu |
Eubacterium |
?
|
ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XIV. FURTHER PURIFICATION AND PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI. |
No |
|
| Bsu |
Eubacterium |
?
|
DNA polymerase III gene of Bacillus subtilis. |
Yes |
|
| Klenow (exo-) |
Eubacterium |
A
|
Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: effect of proximal and distal template damage on DNA synthesis. |
No |
|
| Klenow (exo-) |
Eubacterium |
A
|
In vitro synthesis of uniform poly(dG)-poly(dC) by Klenow exo- fragment of polymerase I. |
Yes |
|
| Klenow (exo-) |
Eubacterium |
A
|
Synthesis of novel poly(dG)-poly(dG)-poly(dC) triplex structure by Klenow exo- fragment of DNA polymerase I. |
No |
|
| Klenow (exo-) |
Eubacterium |
A
|
Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase. |
No |
|
| Vent (exo-) |
Archaeon |
B
|
Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity. |
No |
|
| Deep Vent (exo-) |
Archaeon |
B
|
Unnatural imidazopyridopyrimidine:naphthyridine base pairs: selective incorporation and extension reaction by Deep Vent (exo- ) DNA polymerase. |
No |
|
| Replinase |
Unknown |
?
|
Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity. |
No |
|
| Sequenase |
Virus/Phage |
A
|
Fidelity of Thermococcus litoralis DNA polymerase (Vent) in PCR determined by denaturing gradient gel electrophoresis. |
No |
|
| AMV |
Virus/Phage |
RT
|
Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro. |
No |
|
| AMV |
Virus/Phage |
RT
|
On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase. |
No |
|
| AMV |
Virus/Phage |
RT
|
Purification and partial characterization of equine infectious anemia virus reverse transcriptase. |
No |
|
| AMV |
Virus/Phage |
RT
|
Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. |
No |
|
| T2 |
Virus/Phage |
B
|
Separation of deoxyribo-oligonucleotidases induced by infection with bacteriophage T2. |
No |
|
| Terminal Transferase |
Unknown |
?
|
Characterization of the homopolymer tailing reaction catalyzed by terminal deoxynucleotidyl transferase. Implications for the cloning of cDNA. |
No |
|
| phi29 T434N |
Virus/Phage |
B
|
Primer-terminus stabilization at the psi 29 DNA polymerase active site. Mutational analysis of conserved motif TX2GR. |
Yes |
|
| phi29 R438I |
Virus/Phage |
B
|
Primer-terminus stabilization at the psi 29 DNA polymerase active site. Mutational analysis of conserved motif TX2GR. |
Yes |
|
| phi29 A437G |
Virus/Phage |
B
|
Primer-terminus stabilization at the psi 29 DNA polymerase active site. Mutational analysis of conserved motif TX2GR. |
Yes |
|
| phi29 R438K |
Virus/Phage |
B
|
Primer-terminus stabilization at the psi 29 DNA polymerase active site. Mutational analysis of conserved motif TX2GR. |
Yes |
|
| Bli DNA polymerase |
Eubacterium |
A
|
DNA polymerase from mesophilic and thermophilic bacteria. III. Lack of fidelity in the replication of synthetic polydeoxyribonucleotides by DNA polymerase from Bacillus licheniformis and Bacillus stearothermophilus. |
No |
|
| Thermo JDF-3 pol |
Archaeon |
B
|
Efficient and high fidelity incorporation of dye-terminators by a novel archaeal DNA polymerase mutant. |
Yes |
|
| Human Pol alpha |
Eukaryote |
B
|
Thermostable DNA polymerases. |
No |
|
| Human Pol alpha |
Eukaryote |
B
|
Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations. |
No |
|
| Human Pol alpha |
Eukaryote |
B
|
Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus. |
No |
|
| Human Pol alpha |
Eukaryote |
B
|
Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases. |
No |
|
| Human Pol alpha |
Eukaryote |
B
|
Fidelity and error specificity of the alpha catalytic subunit of Escherichia coli DNA polymerase III. |
No |
|
| T7 (purified without EDTA) |
Virus/Phage |
A
|
Characterization of strand displacement synthesis catalyzed by bacteriophage T7 DNA polymerase. |
Yes |
|
| T7 (purified without EDTA) |
Virus/Phage |
A
|
Two forms of the DNA polymerase of bacteriophage T7. |
Yes |
|
| Eco Pol II |
Eubacterium |
B
|
Thermostable DNA polymerases. |
Yes |
|
| Eco Pol II |
Eubacterium |
B
|
Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins. |
Yes |
|
| Eco Pol II |
Eubacterium |
B
|
Purification and DNA synthesis in cell-free extracts: properties of DNA polymerase II. |
Unspecified |
|
| Eco Pol II |
Eubacterium |
B
|
Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli. |
Yes |
|
| Eco Pol II exo- |
Eubacterium |
B
|
Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli. |
No |
|
| EBV Pol |
Virus/Phage |
B
|
Characterization of 3'-to 5'-exonuclease activity associated with Epstein-Barr virus DNA polymerase. |
Yes |
|
| Human Pol delta |
Eukaryote |
B
|
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. |
Yes |
|
| Human Pol delta |
Eukaryote |
B
|
Thermostable DNA polymerases. |
Yes |
|
| Human Pol delta |
Eukaryote |
B
|
Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus. |
Yes |
|
| Human Pol delta |
Eukaryote |
B
|
Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations. |
Yes |
|
| KF D424A |
Eubacterium |
A
|
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. |
No |
|
| KF D424A |
Eubacterium |
A
|
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. |
No |
|
| KF D355AE357A |
Eubacterium |
A
|
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. |
No |
|
| KF(515-928) |
Eubacterium |
A
|
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. |
No |
|
| Human Pol epsilon |
Eukaryote |
B
|
Thermostable DNA polymerases. |
Yes |
|
| Human Pol epsilon |
Eukaryote |
B
|
Characterization of a large form of DNA polymerase delta from HeLa cells that is insensitive to proliferating cell nuclear antigen. |
Yes |
|
| Human Pol epsilon |
Eukaryote |
B
|
Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations. |
Yes |
|
| Human Pol epsilon |
Eukaryote |
B
|
Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol epsilon and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors. |
Yes |
|
| Human Pol epsilon |
Eukaryote |
B
|
Subunit protein-affinity isolation of Drosophila DNA polymerase catalytic subunit. |
Yes |
|
| Human Pol epsilon |
Eukaryote |
B
|
Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus. |
Yes |
|
| DTok |
Archaeon |
B
|
Crystal structure of an archaebacterial DNA polymerase. |
Yes |
|
| Sce Pol alpha |
Eukaryote |
B
|
Purification and characterization of the 180- and 86-kilodalton subunits of the Saccharomyces cerevisiae DNA primase-DNA polymerase protein complex. The 180-kilodalton subunit has both DNA polymerase and 3'----5'-exonuclease activities. |
Yes |
|
| Sce Pol alpha |
Eukaryote |
B
|
Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme. |
No |
|
| HHV1 |
Virus/Phage |
B
|
Finger domain mutation affects enzyme activity, DNA replication efficiency, and fidelity of an exonuclease-deficient DNA polymerase of herpes simplex virus type 1. |
Yes |
|
| Sce Pol delta |
Eukaryote |
B
|
The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains. |
Yes |
|
| Sce Pol delta |
Eukaryote |
B
|
The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication. |
Yes |
|
| phi29 D332Y |
? |
?
|
An aspartic acid residue in TPR-1, a specific region of protein-priming DNA polymerases, is required for the functional interaction with primer terminal protein. |
Yes |
|
| HIV2 RT |
Virus/Phage |
RT
|
Fidelity of the reverse transcriptase of human immunodeficiency virus type 2. |
No |
|
| Bsu Pol X |
Eubacterium |
X
|
Characterization of a Bacillus subtilis 64-kDa DNA polymerase X potentially involved in DNA repair. |
Yes |
|
| Bsu Pol X |
Eubacterium |
X
|
Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. |
Yes |
|
| Human Pol theta |
Eukaryote |
A
|
The human DINB1 gene encodes the DNA polymerase Poltheta. |
No |
|
| Human Pol theta |
Eukaryote |
A
|
Low-fidelity DNA synthesis by human DNA polymerase theta. |
No |
|
| Pol eta Y52E |
Eukaryote |
Y
|
Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. |
No |
|
| Pol eta Y52F |
Eukaryote |
Y
|
Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. |
No |
|
| Pol eta Y52A |
Eukaryote |
Y
|
Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. |
No |
|
| HHV1 YD12 |
Virus/Phage |
?
|
Finger domain mutation affects enzyme activity, DNA replication efficiency, and fidelity of an exonuclease-deficient DNA polymerase of herpes simplex virus type 1. |
No |
|
| HHV1 L774F |
Virus/Phage |
?
|
Finger domain mutation affects enzyme activity, DNA replication efficiency, and fidelity of an exonuclease-deficient DNA polymerase of herpes simplex virus type 1. |
No |
|
| Tae pol A |
Eukaryote |
B
|
Mammalian proliferating cell nuclear antigen stimulates the processivity of two wheat embryo DNA polymerases. |
No |
|
| Tae pol B |
Eukaryote |
?
|
Mammalian proliferating cell nuclear antigen stimulates the processivity of two wheat embryo DNA polymerases. |
Yes |
|
| Tae pol CI |
Eukaryote |
?
|
Mammalian proliferating cell nuclear antigen stimulates the processivity of two wheat embryo DNA polymerases. |
No |
|
| Tae pol CII |
Eubacterium |
?
|
Mammalian proliferating cell nuclear antigen stimulates the processivity of two wheat embryo DNA polymerases. |
No |
|
| Tgu |
Archaeon |
B
|
Characterization and PCR optimization of the thermostable family B DNA polymerase from Thermococcus guaymasensis |
Yes |
|
| T7 (exo-) |
Virus/Phage |
A
|
Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant. |
No |
|
| Vaccinia Virus Pol |
Virus/Phage |
B
|
Enzymatic processing of replication and recombination intermediates by the vaccinia virus DNA polymerase. |
Yes |
|
| Vaccinia Virus Pol |
Virus/Phage |
B
|
Characterization of a processive form of the vaccinia virus DNA polymerase. |
Yes |
|
| Dme Pol delta |
Eukaryote |
B
|
Drosophila DNA polymerase delta. Purification and characterization. |
Yes |
|
| ASFV pol X |
Virus/Phage |
X
|
Characterization of an African swine fever virus 20-kDa DNA polymerase involved in DNA repair. |
No |
|
| ASFV pol X |
Virus/Phage |
X
|
DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA. |
No |
|
| Eco Pol I* |
Eubacterium |
A
|
Characterization of DNA polymerase I*, a form of DNA polymerase I found in Escherichia coli expressing SOS functions. |
Yes |
|
| SsoDpo1 |
Archaeon |
B
|
Strand annealing and terminal transferase activities of a B-family DNA polymerase. |
Yes |
|
| Pol Kappa (exo-) |
Eukaryote |
Y
|
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. |
No |
|
| Sce Pol III |
Eukaryote |
C
|
Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme. |
Yes |
|
| Sce Pol II |
Eukaryote |
B
|
Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme. |
Yes |
|
| A |
Virus/Phage |
B
|
Properties of the adenovirus DNA polymerase. |
Yes |
|
| A |
Virus/Phage |
B
|
Processive proofreading by the adenovirus DNA polymerase. Association with the priming protein reduces exonucleolytic degradation. |
Yes |
|
| Nf |
Virus/Phage |
B
|
Functional characterization of highly processive protein-primed DNA polymerases from phages Nf and GA-1, endowed with a potent strand displacement capacity. |
Yes |
|
| GA-1 |
Virus/Phage |
B
|
Functional characterization of highly processive protein-primed DNA polymerases from phages Nf and GA-1, endowed with a potent strand displacement capacity. |
Yes |
|
| phi29 (-TPR2) |
Virus/Phage |
B
|
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. |
Yes |
|
| Sce Pol II* |
Eukaryote |
?
|
Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme. |
Yes |
|
| Pab Pol I |
Archaeon |
B
|
PCR performance of the highly thermostable proof-reading B-type DNA polymerase from Pyrococcus abyssi. |
Yes |
|
| EIAV RT |
Virus/Phage |
RT
|
Purification and partial characterization of equine infectious anemia virus reverse transcriptase. |
No |
|
| Pyra exo- |
Archaeon |
?
|
In vitro replication slippage by DNA polymerases from thermophilic organisms. |
No |
|
| Tfu |
Archaeon |
?
|
In vitro replication slippage by DNA polymerases from thermophilic organisms. |
Yes |
|
| MutD5 Pol III |
Eubacterium |
C
|
The base substitution and frameshift fidelity of Escherichia coli DNA polymerase III holoenzyme in vitro. |
No |
|
| Mouse Pol eta |
Eukaryote |
Y
|
Error rate and specificity of human and murine DNA polymerase eta. |
No |
|
| Sce Pol I |
Eukaryote |
B
|
Fidelity of DNA polymerase I and the DNA polymerase I-DNA primase complex from Saccharomyces cerevisiae. |
No |
|
| Human Pol nu |
Eukaryote |
A
|
Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. |
No |
|
| Human Pol nu |
Eukaryote |
A
|
A unique error signature for human DNA polymerase nu. |
No |
|
| Bovine pol elta |
Eukaryote |
B
|
Further studies on calf thymus DNA polymerase delta purified to homogeneity by a new procedure. |
Yes |
|
| Mouse pol elta |
Eukaryote |
?
|
Two forms of DNA polymerase delta from mouse cells. Purification and properties. |
Yes |
|
| Mouse pol elta |
Eukaryote |
?
|
Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. |
Yes |
|
| Poc Pol I |
Archaeon |
B
|
The hyperthermophilic archaeon Pyrodictium occultum has two alpha-like DNA polymerases. |
Yes |
|
| Poc Pol II |
Archaeon |
B
|
The hyperthermophilic archaeon Pyrodictium occultum has two alpha-like DNA polymerases. |
Yes |
|
| Pfu (exo-) |
? |
?
|
DNA polymerases from hyperthermophiles. |
No |
|
| Cal pol gamma |
Eukaryote |
A
|
Purification and characterization of a gamma-like DNA polymerase from Chenopodium album L. |
Yes |
|
| Eco Pol I D424A |
Eubacterium |
A
|
Coordination between the polymerase and 5'-nuclease components of DNA polymerase I of Escherichia coli. |
No |
|
| Eco Pol I - Small Fragment |
Eubacterium |
Non Pol
|
Coordination between the polymerase and 5'-nuclease components of DNA polymerase I of Escherichia coli. |
Unspecified |
|
| Eco Pol I - Small Fragment |
Eubacterium |
Non Pol
|
Deoxyribonucleic acid polymerase: two distinct enzymes in one polypeptide. II. A proteolytic fragment containing the 5' leads to 3' exonuclease function. Restoration of intact enzyme functions from the two proteolytic fragments. |
No |
|
| Eco Pol I - Small Fragment |
Eubacterium |
Non Pol
|
Deoxyribonucleic acid polymerase: two distinct enzymes in one polypeptide. I. A proteolytic fragment containing the polymerase and 3' leads to 5' exonuclease functions. |
No |
|
| Klenow Fragment D424A |
Eubacterium |
A
|
Coordination between the polymerase and 5'-nuclease components of DNA polymerase I of Escherichia coli. |
No |
|
| Eco Pol I Exonuclease I |
Eubacterium |
Non Pol
|
THE DEOXYRIBONUCLEASES OF ESCHERICHIA COLI. IV. AN EXONUCLEASE ACTIVITY PRESENT IN PURIFIED PREPARATIONS OF DEOXYRIBONUCLEIC ACID POLYMERASE. |
Yes |
|
| Eco Pol I Exonuclease II |
Eubacterium |
Non Pol
|
ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XIV. FURTHER PURIFICATION AND PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI. |
Yes |
|
| Eco Pol I Exonuclease II |
Eubacterium |
Non Pol
|
Enzymatic synthesis of deoxyribonucleic acid. XXIX. Hydrolysis of deoxyribonucleic acid from the 5' terminus by an exonuclease function of deoxyribonucleic acid polymerase. |
Yes |
|
| Eco Pol I Exonuclease II |
Eubacterium |
Non Pol
|
THE DEOXYRIBONUCLEASES OF ESCHERICHIA COLI. IV. AN EXONUCLEASE ACTIVITY PRESENT IN PURIFIED PREPARATIONS OF DEOXYRIBONUCLEIC ACID POLYMERASE. |
Yes |
|
| Eco Pol III Holoenzyme |
Eubacterium |
C
|
Dynamics of DNA polymerase III holoenzyme of Escherichia coli in replication of a multiprimed template. |
Yes |
|
| Phi29 D12AD66A |
Virus/Phage |
B
|
Processive proofreading and the spatial relationship between polymerase and exonuclease active sites of bacteriophage phi29 DNA polymerase. |
No |
|
| Pab pol B |
Archaeon |
B
|
Molecular recognition of canonical and deaminated bases by P. abyssi family B DNA polymerase. |
Yes |
|
| Human Pol gamma D198AG200A |
Eukaryote |
A
|
Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers. |
No |
|
